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1、第27卷第5期西安交通大學(xué)學(xué)報(醫(yī)學(xué)版)Vol.27No.52006年10月JournalofXipanJiaotongUniversity(MedicalSciences)Oct.2006牽引成骨矯治硬腭骨缺損動物模型的建立11211任戰(zhàn)平,李錦峰,文星,周洪,劉建華(1.西安交通大學(xué)醫(yī)學(xué)院口腔醫(yī)院口腔頜面外科,陜西西安710004;2.西安高新醫(yī)院口腔科,陜西西安710075)摘要:目的建立一種應(yīng)用牽引成骨技術(shù)矯治硬腭骨缺損畸形的腭裂動物模型。方法1-1.5歲健康家犬8只為實驗對象(6只為實驗組,2只為實驗對照組)。以外科手術(shù)在硬腭部模仿
2、臨床腭裂形成骨缺損裂隙,實驗組同時放置牽引裝置,并形成骨運送盤,8周后觀察裂隙關(guān)閉情況及軟、硬組織形態(tài),了解模型建立后牽引成骨的可行性。結(jié)果實驗組犬經(jīng)安置牽引裝置后可關(guān)閉硬腭處骨裂隙,牽引裝置固定穩(wěn)固,X線顯示骨運送盤可牽移,骨缺損區(qū)裂隙閉合,全身狀況良好。對照組犬8周后,腭裂隙仍存在,大小形狀與手術(shù)時無差別。結(jié)論通過手術(shù)方式建立的腭裂動物模型,可用于牽引成骨技術(shù)矯治腭裂骨缺損,具有一定的可行性。關(guān)鍵詞:牽引成骨;腭裂;動物模型;骨缺損中圖分類號:R782.2文獻(xiàn)標(biāo)識碼:A文章編號:167128259(2006)0520510203Distr
3、actionosteogenesisforcorrectionofcleftpalate:establishmentoftheexperimentalanimalmodel11211RenZhanping,LiJinfeng,WenXing,ZhouHong,LiuJianhua(1.DepartmentofOralandMaxillofacialSurgery,StomatologicalHospital,MedicalSchoolofXipanJiaotongUniversity,Xipan710004;2.DepartmentofSto
4、matology,XipanGaoxinHospital,Xipan710075,China)ABSTRACT:ObjectiveToestablishananimalmodelofcleftpalatefordistractionosteogenesis(DO)treatment.MethodsEighthealthydogs(aged1-1.5years)wereassignedrandomlyinto2groups.Theexperimentalgroupcontainedsixdogsthatunderwent9mm×30mmpala
5、talosteoectomyandDOprocedure.Theothertwodogsreceivedpalateosteoectomyonlyastheexperimentalcontrol.Thecleftofthecontrolswasmeasuredandcomparedwiththedatawhenthedogswerekilledinweek8.ThestateofthecleftandthestabilityoftheDOapparatuswerealsoobservedintheexperimentalgroup.Resul
6、tsAlldogswereingoodconditionwithintheexperimentperiod.Theshapeandwidthofthecleftpalateremainedalmostthesameaswhenitwasmadeoncontroldogs.Intheexperimentalgroup,thewoundhealedin7-10days.TheDOapparatuswasstable.X2rayshowedthatthetransport2discwasdistracted.Theprocedureoftheclo
7、sureofthepalatalcleftwasobserved.ConclusionItisafeasiblewayofestablishingexperimentalcleftpalateindogsbysurgicaloperationforDOtreatment.KEYWORDS:distractionosteogenesis;cleftpalate;animalmodel;bonedefect關(guān)閉腭部裂隙,延長軟腭,為接近正常的腭咽閉采用骨牽引成骨技術(shù)對腭裂硬腭骨缺損進(jìn)行修復(fù)的合創(chuàng)造條件是先天性腭裂手術(shù)治療的目的。多年來動物模型,目
8、的在于觀察骨牽引成骨技術(shù)封閉硬腭裂為了達(dá)到腭咽閉合,許多學(xué)者在手術(shù)方式上不斷改進(jìn)隙的可行性和各階段組織愈合情況。和創(chuàng)新,但硬腭裂隙的骨缺損依舊存在,并不具備正1材料
