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1、Temsirolimus
2、MTORinhibitor
3、CAS#162635-04-3產(chǎn)品服務(wù)工具訂購(gòu)分銷商樣品關(guān)于我們聯(lián)系我們首頁(yè)>>SignalingPathways>>PI3K/Akt/mTORSignaling>>mTOR>>TemsirolimusTemsirolimusmTOR抑制劑相關(guān)產(chǎn)品產(chǎn)品編號(hào)：A8314WYE-354規(guī)格單價(jià)庫(kù)存數(shù)量GDC-0349EvaluationSample￥280.00有貨KU-006379410mg￥850.00有貨Rapamycin(Sirolimus)25mg￥1,790.00有貨Everolimus(RAD001)
4、AZD805550mg￥2,590.00有貨200mg￥6,090.00有貨摩爾計(jì)算器稀釋計(jì)算器客戶使用Apexbio產(chǎn)品發(fā)表的文獻(xiàn)質(zhì)量控制質(zhì)量控制和MSDS化學(xué)結(jié)構(gòu)相關(guān)生物數(shù)據(jù)Viewcurrentbatch:1Purity=99.24%COA(CertificateOfAnalysis)HPLCNMR(NuclearMagneticResonance)MSDS(MaterialSafetyDataSheet)相關(guān)生物數(shù)據(jù)Temsirolimus
5、MTORinhibitor
6、CAS#162635-04-3化學(xué)性質(zhì)CAS號(hào)162635-04-3SDFDownloa
7、dSDF別名Torisel;CCI-779;CCI779;CCI779CO[C@@H]1C[C@H](C[C@@H](C)[C@@H](OC([C@]2([H])CCCCN2C(C([C@]3(O)O[C@@](C[C@H](OC)/C(C)=C/C=C/C=C/[C@H](C[C@@H](CSMILES)C4=O)C)([H])CC[C@H]3C)=O)=O)=O)CC([C@H](C)/C=C(C)/[C@@H](O)[C@H]4OC)=O)CC[C@H]1OC(C(CO)(C)CO)=O分子式C56H87NO16分子量1030.29溶解性SolubleinD
8、MSO>10mM儲(chǔ)存條件Storeat-20°C一般建議為了使其更好的溶解，請(qǐng)用37℃加熱試管并在超聲波水浴中震動(dòng)片刻。儲(chǔ)液可以在零下20℃中保存數(shù)月。試用裝：藍(lán)冰運(yùn)輸。運(yùn)輸條件其他可選規(guī)格：常溫運(yùn)輸或根據(jù)您的要求用藍(lán)冰運(yùn)輸。生物活性描述Temsirolimus(CCI-779）是mTOR的一個(gè)特定的抑制劑，IC50值為1.76μM。靶點(diǎn)mTORIC501.76μM實(shí)驗(yàn)操作Cellexperiment:[1]CelllinesPC-3andDU145cellsThesolubilityofthiscompoundinDMSOis>10mM.Generaltipsf
9、orobtainingahigherconcentration:Pleasewarmthetubeat37°Cfor10mPreparationmethodinutesand/orshakeitintheultrasonicbathforawhile.Stocksolutioncanbestoredbelow-20°Cforseveralmonths.Reactingcondition100nM,3daysThegrowthandcolony-formationofbothcelllineswereinhibitedinaconcentration-depende
10、ntmannerbyCCI-779.Followinga3-dayexposuApplicationsreto100nmol/LCCI-779,thenumbersofcolony-formingPC-3andDU145cellswere0.18±0.09and0.37±0.03,respectively,comparedwithcontrols.Animalexperiment:[2]AnimalmodelsNudemicebearingDAOYxenograftsDosageformIntraperitonealinjection,20mg/kg,daily3
11、5for1,2or4weeksor100mg/kgondays1and12CCI-779administeredat20mg/kg5days/weekfor1and2weeksyielded1.6-and2.4-folddelayedtumorgrowth.Timetoreach5-foldtumorvolumewassignificantlygreaterinanimalstreatedfor1weekor2weekscomparedwithcontrolanimals.RetreatmentoflargetumorswithCApplicationCI-779
12、for2w
