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1、DrugDeliverySystem藥物投遞系統(tǒng)生科系04級(jí)黃玫璇891672生科系04級(jí)許哲源891659生科系04級(jí)蕭宏展891631生科系04級(jí)楊淳竣891625藥物釋控系統(tǒng)黃玫璇891672藥物釋控系統(tǒng)1.何謂藥物釋控2.發(fā)展釋控的優(yōu)點(diǎn)3.藥物釋控的種類A.DiffusioncontrolledB.ChemicallycontrolledC.Solvent-activatedcontrolled藥物釋控系統(tǒng)1.何謂藥物釋控2.發(fā)展釋控的優(yōu)點(diǎn)3.藥物釋控的種類A.DiffusioncontrolledB.ChemicallycontrolledC.Solvent-activatedc
2、ontrolled【藥物釋控】：DrugControlledReleaseSystem將藥物以特殊的化學(xué)包覆，讓藥物在某一種狀態(tài)(如PH值改變)下適時(shí)(ex:延長(zhǎng))適量釋出。這種控釋劑型的技術(shù)發(fā)展，目前廣泛地應(yīng)用於一般的製藥化學(xué)工業(yè)中。藥物釋控系統(tǒng)1.何謂藥物釋控2.發(fā)展釋控的優(yōu)點(diǎn)3.藥物釋控的種類A.DiffusioncontrolledB.ChemicallycontrolledC.Solvent-activatedcontrolledPotentialAdvantagesofControlledReleaseSystemsmaintenanceofdrugsattherapeutic
3、allydesirablelevels2.theabilitytolocalizedrugstotargetorganstominimizesystemiceffects3.improvedpatientcompliance4.protectionfromdegradationfordrugswithshortinvivolifetimes.ControlledReleasevs.SingleDoseSideEffectsTherapeuticDoseDesiredRange藥物釋控系統(tǒng)1.何謂藥物釋控2.發(fā)展釋控的優(yōu)點(diǎn)3.藥物釋控的種類A.DiffusioncontrolledB.Che
4、micallycontrolledC.Solvent-activatedcontrolledTypesofControlledReleaseDevices【Diffusioncontrolled】Diffusionthroughmembraneorbulkpolymer【Chemicallycontrolled】˙polymererosion：surfaceerosion,bulkerosion(combinationoferosionanddiffusion)˙pendentchain【Solvent-activatedcontrolled】˙osmotictransportofwate
5、rthroughsemipermeablemembrane˙waterpenetrationintoglassypolymer1.Diffusioncontrolled【Stomach/Intestine–Liquid】【Capsuleedge–Gel】Biocompatiblepolymer【Capsulecenter–Dry】Allowsfordelayedrelease△releaseratesaredeterminedbypolymerpropertyandpartitioncoefficientofthedrugtobereleased.△advantage˙drugdiffus
6、esoutofmatrixatdefinedrate△disadvantage˙efficiencyofdiffusionoflargemolecules˙dangerof‘dosedumping’inbarriersystems2.Chemicallycontrolled˙erosion：Surfaceerosion,Bulkerosion△capsuleiserodedbytheacidsinthestomach△advantage˙injectable(microspheres)˙biodegradable(neednotberemovedsurgically)△disadvanta
7、ge˙difficulttostoponceinjected2.Chemicallycontrolled˙pendentchain△drugiscovalentlyboundtothepolymerandisreleasedbybondscissionowingtowaterorenzymes3.Solvent-activatedcontrolled△theactiveagentisdissolvedordisperse
