Progesterone receptor targeting with radiolabelled steroids An approach in predicting breast cancer response to therapy

Progesterone receptor targeting with radiolabelled steroids An approach in predicting breast cancer response to therapy

ID：40723774

大?。?.46 MB

頁數(shù)：19頁

時間：2019-08-06

Progesterone receptor targeting with radiolabelled steroids An approach in predicting breast cancer response to therapy_第1頁
Progesterone receptor targeting with radiolabelled steroids An approach in predicting breast cancer response to therapy_第2頁
Progesterone receptor targeting with radiolabelled steroids An approach in predicting breast cancer response to therapy_第3頁
Progesterone receptor targeting with radiolabelled steroids An approach in predicting breast cancer response to therapy_第4頁
Progesterone receptor targeting with radiolabelled steroids An approach in predicting breast cancer response to therapy_第5頁
資源描述：

《Progesterone receptor targeting with radiolabelled steroids An approach in predicting breast cancer response to therapy》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。

1、JournalofSteroidBiochemistry&MolecularBiology137(2013)223–241ContentslistsavailableatScienceDirectJournalofSteroidBiochemistryandMolecularBiologyjournalhomepage:www.elsevier.com/locate/jsbmbReviewProgesteronereceptortargetingwithradiolabelledsteroids:Anap

2、proachinpredictingbreastcancerresponsetotherapySusanaaaaba,?Cunha,LurdesGano,GoretiRibeiroMorais,ThiesThiemann,MariaCristinaOliveiraaUnidadedeCiênciasQuímicaseRadiofarmacêuticas,IST/ITN,InstitutoSuperiorTécnico,UniversidadeTécnicadeLisboa,EstradaNacional1

3、0,2686-953Sacavém,PortugalbFacultyofScience,UnitedArabEmiratesUniversity,UnitedArabEmiratesarticleinfoabstractArticlehistory:SteroidreceptorshavedemonstratedtobepotentiallyusefulbiologicaltargetsforthediagnosisandReceived4December2012therapyfollow-upofhor

4、monallyresponsivecancers.Theover-expressionoftheseproteinsinhumanReceivedinrevisedform24April2013cancercellsaswellastheirbindingcharacteristicsprovidesafavourablemechanismforthelocalization30April2013Acceptedofmalignanttumours.Theneedfornewerandmoreselect

5、iveprobestonon-invasivelyassesssteroidreceptorKeywords:expressioninhormone-responsivetumourshasencouragedthesynthesisandthebiologicalevaluationofseveralsteroidalderivativeslabelledwithpositronandgammaemitters.ThephysiologicalBreastcancereffectsProgesteron

6、eofthesteroidhormoneprogesteronearemediatedbytheprogesteronereceptor(PR).SincePRexpressionisstimulatedbytheoestrogenreceptor(ER),PRstatushasbeenconsideredasabiomarkerofProgesteronereceptorERPETactivityanditsvalueforpredictingandmonitoringtherapeuticef?cac

7、yofhormonaltherapyhasbeenstudied.SPECTImagingofPR-expressingbreastcancerpatientsunderhormonaltherapymaybeadvantageous,sinceImagingtheresponsetotherapycanbemoreaccuratelypredictedafterquanti?cationofbothERandPRTumourtargetingstatus.Thus,ligandsforPRtargeti

8、ng,althoughmuchlessexploredthanERligands,havegainedsomeimportancelatelyaspotentialPETandSPECTtumourimagingagents.Inthisreview,wepresentabriefsurveyofexploredapproachesforprogesteronetargetingusingradiolabelledproges

當(dāng)前文檔最多預(yù)覽五頁，下載文檔查看全文

此文檔下載收益歸作者所有

當(dāng)前文檔最多預(yù)覽五頁，下載文檔查看全文
溫馨提示：
1. 部分包含數(shù)學(xué)公式或PPT動畫的文件，查看預(yù)覽時可能會顯示錯亂或異常，文件下載后無此問題，請放心下載。
2. 本文檔由用戶上傳，版權(quán)歸屬用戶，天天文庫負(fù)責(zé)整理代發(fā)布。如果您對本文檔版權(quán)有爭議請及時聯(lián)系客服。
3. 下載前請仔細閱讀文檔內(nèi)容，確認(rèn)文檔內(nèi)容符合您的需求后進行下載，若出現(xiàn)內(nèi)容與標(biāo)題不符可向本站投訴處理。
4. 下載文檔時可能由于網(wǎng)絡(luò)波動等原因無法下載或下載錯誤，付費完成后未能成功下載的用戶請聯(lián)系客服處理。