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1、Downloadedfromhttp://rsfs.royalsocietypublishing.org/onAugust11,2018InterfaceFocusdoi:10.1098/rsfs.2011.0123PublishedonlineREVIEWPoly(lactide-co-glycolide)porousscaffoldsfortissueengineeringandregenerativemedicineZhenPanandJiandongDing*StateKeyLaborato
2、ryofMolecularEngineeringofPolymers,DepartmentofMacromolecularScience,LaboratoryofAdvancedMaterials,FudanUniversity,Shanghai200433,ChinaPorousscaffoldsfabricatedfrombiocompatibleandbiodegradablepolymersplayvitalrolesintissueengineeringandregenerativemed
3、icine.Amongvariousscaffoldmatrixmaterials,poly(lactide-co-glycolide)(PLGA)isaverypopularandanimportantbiodegradablepolye-sterowingtoitstunabledegradationrates,goodmechanicalpropertiesandprocessibility,etc.ThisreviewhighlightstheprogressonPLGAscaffolds.
4、Inthelatestdecade,somefacilefab-ricationapproachesatroomtemperaturewereputforward;moreappropriateporestructuresweredesignedandachieved;themechanicalpropertieswereinvestigatedbothfordryandwetscaffolds;alongtimebiodegradationofthePLGAscaffoldwasobserveda
5、ndathree-stagemodelwasestablished;eventheeffectsofporesizeandporosityoninvitrobiodegradationwererevealed;thePLGAscaffoldshavealsobeenimplantedintoanimals,andsometissueshavebeenregeneratedinvivoafterloadingcellsincludingstemcells.Keywords:poly(lactide-c
6、o-glycolide)(PLGA);porousscaffolds;tissueengineering;biodegradation;mechanicalproperties1.INTRODUCTIONotherhand,appropriatemechanicalpropertiesanddegradationratesofporousscaffoldsarealsoveryimpor-Biodegradablematerialsareveryimportantinmedicaltant[10,1
7、1].Amonganumberofscaffoldmaterialsapplicationssuchastissueengineering,tissueinduction,reportedsofar,poly(lactide-co-glycolide)(PLGA)isdrug-controlledreleaseandinternal?xation[1–3].Athemostpopularbiodegradablepolymer[3,4,9,12],speci?cphysicalformofmater
8、ials,porousscaffoldsowingtoitsprominentadvantagessuchasadjustabilityofhasbeenpaidmuchattentioninthelatestdecadedegradationrates,goodmechanicalpropertiesespeciallyowingtotheemergenceofmodernregenerativemedi-toughness,andexcellentprocessi
