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1、Y151015治療前血小板和淋巴細(xì)胞比值與原發(fā)性肝癌（肝細(xì)胞型）經(jīng)TACE治療療效及預(yù)后的相關(guān)性馬雙雙，宋金龍*，李金鵬，陳華，肖婉作者單位：250117濟南，山東省腫瘤醫(yī)院外九科山東省醫(yī)學(xué)科學(xué)院；*通訊作者聯(lián)系電話：13969182731摘要目的：評價治療前外周血血小板和淋巴細(xì)胞比值（PLR）與III期原發(fā)性肝癌TACE治療療效及預(yù)后的相關(guān)性。方法：回顧性分析我院收治的95例經(jīng)TACE治療原發(fā)性肝癌患者的臨床相關(guān)資料，繪制ROC曲線分析PLR與TACE治療療效的關(guān)系，并預(yù)測TACE治療療效的最佳臨界（
2、cutoff）值。建立Logistic回歸模型分析影響TACE治療療效的獨立相關(guān)因素，采用單因素及Cox回歸模型分析PLR和其他臨床病理因素與3年生存率的關(guān)系。結(jié)果：PLR與TACE的療效顯著相關(guān)，預(yù)測TACE治療療效的PLR最佳臨界值約為89，敏感性和特異性分別為0.869和0.676?；颊逷LR>89的3年生存率低于PLR≤89（48.3%vs.87.5%），差異有統(tǒng)計學(xué)意義（P=0.026）。通過單因素分析顯示肝硬化、PLR、Child-Pugh分級、腫瘤直徑>5cm、門脈癌栓、BCLC分級是影響
3、HCC患者預(yù)后的危險因素。多因素Cox回歸分析結(jié)果顯示，肝硬化、PLR、腫瘤直徑>5cm、門脈癌栓形成及合并肝動脈-門靜脈瘺是影響HCC患者預(yù)后的獨立危險因素。結(jié)論：治療前PLR可作為預(yù)測肝癌TACE臨床療效的指標(biāo)之一，術(shù)前PLR作為一種全身炎癥反應(yīng)指標(biāo)，可有效預(yù)測TACE治療療效并且對預(yù)后評估有一定的臨床價值。關(guān)鍵詞原發(fā)性肝癌肝動脈化療栓塞術(shù)（TACE）血小板與淋巴細(xì)胞比值(PLR)門靜脈癌栓（PVTT）肝動脈-門靜脈瘺預(yù)后Associationofpre-treatmentplatelet-to-l
4、ymphocyteratioswithresponsetotranscatheterarterialehemoembolizationandclinicaloutcomesofhepatocellularcarcinomapatientsMAShuangshuang,SONGJinlong*,LIJinpeng,etal.DepartmentofSurgicalOncology(InterventionalTherapy),ShandongCancerHospitalandInstitute,Shand
5、ongAcademyofMedicalSciences,Jinan,Shandong250117,P.R.ChinaAbstractObjective:Toevaluatethepredictivevalueofpretreatmentplatelet-to-lymphocyteratios(PLRs)inresponsetotranscatheterarterialehemoembolizationandprognosticoutcomeinpatientswithStagesIIIhepatocel
6、lularcarcinomacancer.Methods:Aninvestigationwasconductedon95patientswithhepatocellularcarcinomacancer,whounderwenttranscatheterarterialehemoembolizationinShanDongTumorHospital,ShanDong.Areceiveroperatingcharacteristic(ROC)curvewasusedtodeterminethebestPL
7、Rcut-offvalueinpredictingtheresponsetotranscatheterarterialehemoembolization.Therelationshipsbetweenthepretreatmentvariablesandtheresponsetotranscatheterarterialehemoembolizationwereassessedinunivariateandmultivariatesettings.Theoverallthree-yearsurvival
8、rateswereanalyzedusingthelog-ranktestandCoxregressionmodel.Results:TheresponsetotranscatheterarterialehemoembolizationwasassociatedwithPLR.Atthethresholdof89.0,thePLRwas86.9%sensitiveand67.6%specific.Multivariateanalysissh
