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1、乙肝患者血清前S1抗原檢測(cè)及其臨床價(jià)值［摘要］目的探討和分析血清前S1抗原(Pi、esl)在乙肝感染患者臨床檢測(cè)中的檢測(cè)方法和應(yīng)用價(jià)值。方法方便選取該院2014年3月一2015年2月所收治的乙型肝炎感染患者190例作為研究對(duì)象，通過酶聯(lián)免疫吸附試驗(yàn)方法，檢測(cè)患者的血清前S1抗原和乙肝病毒5項(xiàng)指標(biāo)，并運(yùn)用熒光定量PCR法，來檢測(cè)患者的HBV-DNA指標(biāo)，然后分析血清前S1抗原和HBV-DNA和HBeAg指標(biāo)的陽性。結(jié)果經(jīng)檢測(cè)，以HBV-DNA陽性為標(biāo)準(zhǔn)，患者血清前S1抗原和HBV-DNA檢測(cè)的陽性率分別為96.9%和98.5%,患者的該兩項(xiàng)指標(biāo)對(duì)比，差異無統(tǒng)計(jì)學(xué)意義(x
2、2=0.037,P>0.05)；以血清HBsAg指標(biāo)陽性結(jié)果為標(biāo)準(zhǔn)，患者血清前S1抗原和HBeAg指標(biāo)檢測(cè)的陽性率分別為8&5%和96.6%,患者的該兩項(xiàng)指標(biāo)對(duì)比，差異無統(tǒng)計(jì)學(xué)意義(x2=1.362,P>0.05)o結(jié)論乙肝病毒前S1抗原可以較好地反映出HBV的復(fù)制狀況，對(duì)于乙肝感染者開展血清前S1抗原檢測(cè)，能夠明顯地降低單純血清學(xué)檢驗(yàn)中的假陰性率，并降低誤診和漏診的發(fā)生率，值得臨床推廣。［關(guān)鍵詞］乙肝前S1抗原；乙肝病毒；乙肝感染［中圖分類號(hào)］R446.6［文獻(xiàn)標(biāo)識(shí)碼］A［文章編號(hào)］1674-0742(2016)04(c)-0098-02［Abstract］Obje
3、ctiveTodiscussandanalyzethedetectionmethodandapplicationvalueofserumpre~slantigenintheclinicaldetectionofhepatitisBpatients.Methods190casesofhepatitisBpatientsadmittedandtreatedinourhospitalfromMarch2014toFebruary2015wereselectedastheresearchobjects,theserumpre~slantigenand5indexesofhep
4、atitisBvirusofpatientsweredetectedbytheenzyme-linkedimmunosorbentassaymethod,theIIBV-DNAindexofpatientswasdetectedbythefluoresceneequantitativePCRmethod,andthenthepositiveratesofserumpre-siantigen,HBV-DNAandHBeAgindexesandcorrelationbetweenthemwereanalyzed.ResultsThepositiveratesofserum
5、pre~slantigenandHBV-DNAdetectionwererespectively96.9%and98.5%takingtheIIBV-DNApositiveresultsasstandards,andtherewasnoobviousdifferencebycomparisonandtherewasnostatisticalsignificance,(x2二0.037,P>0?05)；thepositiveratesofserumpre~slantigenandHBeAgindexdetectionofpatientswererespectively8
6、8.5%and96.6%takingtheserumHBsAgindexpositiveresultsasstandards,andtherewasalsonoobviousdifferencebycomparison，andtherewasnostatisticalsignificance,(x2二1.362,P>0.05)?ConclusionHepatitisBviruspre-s1antigencanbetterreflectthereplicationstatusofHBV,anditcanobviouslydecreasethefalsenegativer
7、ateofsimpleserologictestinganddecreasetheincidenceratesofmisdiagnosisandmissedcliagnosistocarryoutthedetectionofserumpre—siantigenforpatientswithhepatitisBinfection,whichisworthclinicalpromotion..Keywords］HepatitisBpre-s1antigen；HepatitisBvirus；HepatitisBinfection近些年來，乙肝病毒攜帶者的患
