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1、乙肝患者血清前S1抗原檢測(cè)及其臨床價(jià)值[摘要]目的探討和分析血清前S1抗原(Pi、esl)在乙肝感染患者臨床檢測(cè)中的檢測(cè)方法和應(yīng)用價(jià)值。方法方便選取該院2014年3月一2015年2月所收治的乙型肝炎感染患者190例作為研究對(duì)象,通過酶聯(lián)免疫吸附試驗(yàn)方法,檢測(cè)患者的血清前S1抗原和乙肝病毒5項(xiàng)指標(biāo),并運(yùn)用熒光定量PCR法,來檢測(cè)患者的HBV-DNA指標(biāo),然后分析血清前S1抗原和HBV-DNA和HBeAg指標(biāo)的陽性。結(jié)果經(jīng)檢測(cè),以HBV-DNA陽性為標(biāo)準(zhǔn),患者血清前S1抗原和HBV-DNA檢測(cè)的陽性率分別為96.9%和98.5%,患者的該兩項(xiàng)指標(biāo)對(duì)比,差異無統(tǒng)計(jì)學(xué)意義(x
2、2=0.037,P>0.05);以血清HBsAg指標(biāo)陽性結(jié)果為標(biāo)準(zhǔn),患者血清前S1抗原和HBeAg指標(biāo)檢測(cè)的陽性率分別為8&5%和96.6%,患者的該兩項(xiàng)指標(biāo)對(duì)比,差異無統(tǒng)計(jì)學(xué)意義(x2=1.362,P>0.05)o結(jié)論乙肝病毒前S1抗原可以較好地反映出HBV的復(fù)制狀況,對(duì)于乙肝感染者開展血清前S1抗原檢測(cè),能夠明顯地降低單純血清學(xué)檢驗(yàn)中的假陰性率,并降低誤診和漏診的發(fā)生率,值得臨床推廣。[關(guān)鍵詞]乙肝前S1抗原;乙肝病毒;乙肝感染[中圖分類號(hào)]R446.6[文獻(xiàn)標(biāo)識(shí)碼]A[文章編號(hào)]1674-0742(2016)04(c)-0098-02[Abstract]Obje
3、ctiveTodiscussandanalyzethedetectionmethodandapplicationvalueofserumpre~slantigenintheclinicaldetectionofhepatitisBpatients.Methods190casesofhepatitisBpatientsadmittedandtreatedinourhospitalfromMarch2014toFebruary2015wereselectedastheresearchobjects,theserumpre~slantigenand5indexesofhep
4、atitisBvirusofpatientsweredetectedbytheenzyme-linkedimmunosorbentassaymethod,theIIBV-DNAindexofpatientswasdetectedbythefluoresceneequantitativePCRmethod,andthenthepositiveratesofserumpre-siantigen,HBV-DNAandHBeAgindexesandcorrelationbetweenthemwereanalyzed.ResultsThepositiveratesofserum
5、pre~slantigenandHBV-DNAdetectionwererespectively96.9%and98.5%takingtheIIBV-DNApositiveresultsasstandards,andtherewasnoobviousdifferencebycomparisonandtherewasnostatisticalsignificance,(x2二0.037,P>0?05);thepositiveratesofserumpre~slantigenandHBeAgindexdetectionofpatientswererespectively8
6、8.5%and96.6%takingtheserumHBsAgindexpositiveresultsasstandards,andtherewasalsonoobviousdifferencebycomparison,andtherewasnostatisticalsignificance,(x2二1.362,P>0.05)?ConclusionHepatitisBviruspre-s1antigencanbetterreflectthereplicationstatusofHBV,anditcanobviouslydecreasethefalsenegativer
7、ateofsimpleserologictestinganddecreasetheincidenceratesofmisdiagnosisandmissedcliagnosistocarryoutthedetectionofserumpre—siantigenforpatientswithhepatitisBinfection,whichisworthclinicalpromotion..Keywords]HepatitisBpre-s1antigen;HepatitisBvirus;HepatitisBinfection近些年來,乙肝病毒攜帶者的患