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《阿托伐他汀對(duì)急性冠脈綜合征患者高敏一c反應(yīng)蛋白及血脂水平的影響》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在工程資料-天天文庫(kù)。
1、阿托伐他汀對(duì)急性冠脈綜合征患者高敏一C反應(yīng)蛋白及血脂水平的影響王國(guó)敏海南省瓊海市人民醫(yī)院急診科海南瓊海571400【摘要】目的：觀察高皺C(jī)反應(yīng)蛋口(hs—CRP)及血脂水平的變化，評(píng)估阿托伐他汀治療急性冠脈綜合癥(ACS)患者的療效。方法：選擇72例急性冠脈綜合癥患者，隨機(jī)分為治療組及對(duì)照組(每組各36例)，治療組用常規(guī)加阿托伐他汀20mg?d-l對(duì)照組僅為常規(guī)治療。治療前、1個(gè)月、3個(gè)月分別檢測(cè)兩組患者h(yuǎn)s—CRP和血脂水平，并對(duì)比分析，隨訪兩組主要心血管事件(MACE)包括全因性死亡、非致死性心肌梗
2、死、靶血管再次血運(yùn)重建。隨訪為期1年。結(jié)果：治療組治療1個(gè)月后hs—CRP、總膽固醇明顯低于治療前水平(P<0.05),治療3個(gè)月后兩者較治療前更明顯降低(P<0.01)；治療組治療3個(gè)月后，低密度膽固醇、甘油三酯均較治療前明顯降低(P<0.05),高密度膽固醇治療前后變化不明顯。而對(duì)照組hs-CRP及血脂與治療前相比，均無(wú)明顯變化。治療組MACE發(fā)生率明顯低于對(duì)照組(P<0.05)。結(jié)論：阿托伐他汀降低ACS患者h(yuǎn)s—CRP及總膽固醇、低密度膽固醇及甘油三酯水平，有助于減少M(fèi)A
3、CE發(fā)生率?！娟P(guān)鍵詞】阿托伐他??；急性冠脈綜合癥；高皺C(jī)RP；血脂【屮圖分類號(hào)1R541.4【文獻(xiàn)標(biāo)識(shí)碼］B【文章編號(hào)11674-8999(2015)8-0203-02Influencesofatorvastatintherapyonhs-CRPandlipidslevelsinpatientswithacutecoronarysyndrome(ACS)WANGGuoMin(DepartmentofEmergency,ThePeople’SHospitalofQionghai,Hainan5
4、71400,China)[Abstract]Objective：Toobservethechangesofhigh-sensitivityCreactiveprotein(hs?CRP)、lipidslevels,andtoevaluatetheeffectofatorvastatintherapyinpatientswithACS.Methods：Seventy-twopatientswithACSwererandomlydividedintotreatmentandcontrolgroups(36c
5、aseseach),treatmentgroupwithatorvastatintherapy(20mg?d-l)plusroutinetherapy,whilecontrolgroupweretreatedwithroutinetherapyonly,hs-CRPandlipidslevelsintwogroupsweremeasuredatbeforetherapy^1month^3months、aftertreatment.Theresultswerecompared.Theincideneeof
6、majoradversecardiacevents(MACE)includingdeath,nonfatalmyocardialinfarction,andtargetvesselrevascularizationwerefollowedfor1yearaftertreatment.Results：At1monthaftertreatment,thelevelsofhs一CRPandtotalcholesterol(TC)intreatmentgroupswerelowerthanthoseofbefo
7、retreatment(P<0.05),aftertreatmentfor3months,thelevelsofhs-CRPandTCweresignificantlydecreasedthanthoseofbeforetreatment(P<0.01).At3monthsaftertreatment,thelevelsoflowdensitylipoproteincholesterol(LDL-C)andtriglyceride(TG)intreatmentgroupwerelowerth
8、anthoseofbeforetreatment(P<0.05),whilhighdensitylipoproteincholesterol(HDL-C)hadnosignificantlydiffereneebeforeandaftertreatment.Therewerenodifferencesincontrolgroupbeforeandaftertreatment-TheoccurreneeratesofMACEintrea
