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1、益生圉治療肝哀竭【摘要】目的:探討益生菌治療肝衰竭對(duì)患者的血漿內(nèi)毒素水平、腸道菌群數(shù)量和細(xì)胞因子水平的影響。方法:選取筆者所在醫(yī)院治療的肝衰竭患者76例,隨機(jī)分為對(duì)照組和觀察組,各38例。對(duì)照組使用對(duì)癥、保肝和白蛋白進(jìn)行治療,觀察組在對(duì)照組治療的基礎(chǔ)上給予益生菌治療,并在進(jìn)彳亍治療前和治療后進(jìn)彳亍檢測(cè)相關(guān)指標(biāo)。結(jié)果:對(duì)照組治療前后各項(xiàng)指標(biāo)比較差異均無(wú)統(tǒng)計(jì)學(xué)意義(P>0.05);觀察組治療后腸道益牛菌菌群的菌落數(shù)均明顯高于対照組和治療前,而酵母樣真菌的菌落數(shù)明顯下降,血漿內(nèi)毒素、IL-6、IL-1.TNF-a的水平比對(duì)照組和治療前均明顯降低,比較差異均有統(tǒng)計(jì)學(xué)意義(P〈0?05)。結(jié)論:益
2、生菌能夠使患者的菌群失調(diào)得到改善,使腸道菌群失調(diào)所產(chǎn)生的內(nèi)毒素減少,使血漿的炎性細(xì)胞因子表達(dá)減輕,從而達(dá)到輔助治療肝衰竭和改善肝功能的目的?!娟P(guān)鍵詞】益生菌;肝衰竭;內(nèi)毒素;腸道菌群;細(xì)胞因子中圖分類號(hào)R575.3文獻(xiàn)標(biāo)識(shí)碼A文章編號(hào)1674-6805(2016)8-0003-02[Abstract]Objective:Toexploretheinfluenceofprobioticstreatmentonplasmaendotoxin1evel,thenumbersofintestinalfloraandthelevelsofcytokinesofliverfailurepatient
3、s?Method:76patientswithliverfailureweretreatedinourhospital,whichwererandomlydividedintothecontrolgroupandtheobservationgroup,38casesineachgroup,thecontrolgroupwasgivensymptomatic,hepatoprotectiveandalbumintreatment,theobservationgroupwasgivenprobioticsonthebasisofthecontrolgroup,therelatedindexe
4、sweredetectedbeforeandaftertreatment.Result:Tnthecontrolgroup,therewasnogreatdifferenceoftheindexesbeforeandaftertreatment(P>0.05);Aftertreatment,thenumberofcoloniesofintestinalprobioticsgroupoftheobservationgroupwassignificantlyhigherthanthatincontrolgroupandtheformer,theyeastfungalcolonycountde
5、creasedobviously,plasmaendotoxin,IL-l,IL~6,TNF-alevelsoftheobservationgroupweresignificantlylowerthanthoseofthecontrolgroupandtheformer,comparativedifferenceswerestatisticallysignificant(P<0.05).Conclusion:Probioticscanenablepatientstofloraimbalaneeimproved,andreducethecausedbythedisordersofthegu
6、tbacteriaendotoxin,inflammatorycellsexpresserelief,soastoachievetheadjuvanttreatmentofliverfailureandimproveliverfunction.[Keywords]Probiotics;Liverfailure;Endotoxin;Intestinalflora;Cel1factorFirst-authorsaddress:People"sHospitalofXinchengCountry,Xincheng546200,Chinadoi:10.14033/j.enki.cfmr.2016.
7、8.002肝衰竭是比較嚴(yán)重的一種肝臟疾病,此病變化較快,并發(fā)癥較多,治療比較困難,而且預(yù)后比較差[1]?,F(xiàn)在認(rèn)為,肝衰竭患者一般情況下免疫功能低下,腸道的菌群失調(diào),致使體內(nèi)的內(nèi)毒素增多,這種腸源性的內(nèi)毒素的血癥導(dǎo)致肝衰竭加重。所以,治療肝衰竭的一種比較好的方法就是使腸道失調(diào)的菌群恢復(fù)[2]。本文就應(yīng)用益生菌來(lái)治療肝衰竭患者的腸道中的菌群失調(diào),并和常規(guī)對(duì)照組比較分析,現(xiàn)報(bào)道如下。1資料與方法1.1一般資料選取筆者所在醫(yī)院2010-20