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1、肝衰竭的治療XXX市人民醫(yī)院支持治療1病因治療2并發(fā)癥治療4其他治療3CONTENTS目錄一、支持治療Bedrest,reducingenergyconsumption,andalleviating(緩解)theburdenoftheliver(Ⅲ);MonitoringPTA/INR,bloodammonia(血氨)andbloodbiochemicalindices,analyzingarterialbloodlactate(乳酸),endotoxin(內(nèi)毒素),hepadnavirusmarkers(嗜肝DNA病毒),ceruloplasmin(銅蘭
2、蛋白),antibodiesofautoimmuneliverdiseases(自免肝抗體),andexaminingabdomenbyB-ultrasound(liver,gallbladder,spleenandpancreas,ascites),takingchestX-rayandelectro-cardiography(ECG)(Ⅲ);一、支持治療c.Enteralnutritionispreferred,includinghigh-carbohydrate(碳水化合物),low-fat,moderateproteindiet,providing
3、35-40kcal/kgtotalcalories;forpatientswithHE,proteinintakebyintestinalshouldbelimited;forpatientswithhypoalimentation(營養(yǎng)不良),adequateliquidandvitaminsupplementationshouldbedeliveredintravenouslytoguaranteeadailytotalenergyintake(Ⅲ);d.Itisnecessarytoactivelyrectify(糾正)lowproteinemia,
4、andsupplyalbuminorfreshplasmaandbloodcoagulationfactorsasappropriate(Ⅲ);e.Monitoringarterialbloodgasisdoneifrequired,correctingthedisturbanceofwaterandelectrolytesaswellasacid-baseequilibrium,especiallyhyponatremia(低鈉血癥),hypochloraemia(低氯血癥),hypopotassaemia(低鉀血癥)andalkalosis(堿中毒)(
5、Ⅲ);Hyponatremiaisacommoncomplicationofdecompensated(失代償)cirrhosis.Hyponatremia,refractoryascites(頑固性腹水)andacutekidneyinjury(AKI)arecommonlyinterrelatedwitheachother.Waterrestriction,asappropriate,combinedwithdiuretics(利尿劑),iseffectiveforhyponatremiaandthus,preventsthesubsequentcom
6、plications;一、支持治療ForHBVDNA(+)patientswithliverfailure,antiviraltherapyisrelativelyeffectiveintheearlyandmiddlestages;butforpatientswithadvancedstageofliverfailure,duetotheseverelydamageofresidualhepatocytesandregenerativecapacityoftheliver,antiviraltreatmentisunlikelytoimproveoutc
7、ome;Fordrug-inducedliverinjury(DILI),anypresumedorpossibleoffendingagentshouldbestoppedimmediately(Ⅲ),documentingallagentstakenoverthepastsixmonthsincludingprescriptiondrugs,non-prescriptiondrugs,herbs,dietarysupplements(Ⅲ)二、病因治療Forpatientsaffectedbyparacetamol(醋氨酚)、acetaminophen(
8、APAP)(對乙酰氨基酚),N-acetylcysteine(NA