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1、Chapter11SARSCoronavirus:AnAnimalReservoir?YiGuan,HumeField,GavinJDSmithandHonglinChentransmittedtothede?nedtargetpopula-Introductiontion’.Thus,adiscretehumanpopulation,TheemergenceofSARSanditssubsequentananimalpopulation,oranecologicalrapidglobalspreadcausedalarminpubliccommun
2、itycanberegardedasareservoir.Ithealthcirclesworldwide.Theunknownae-isalsoimportanttorecognizethat,foranytiologyofthisnovel,atypicalpneumoniapathogen,multiplereservoirsarepossible.wasonereasonforthealarm.Severalputa-Anunderstandingoftheseconceptsisnec-tiveaetiologicalagentswerec
3、onsideredini-essarytograspthepotentialcomplexityoftially,withapreviouslyundescribednovelthetaskofidentifyingthesourceofhumancoronavirus(Coronaviridae)?nallyshowninfection,andthusfortheidenti?cationoftoberesponsible(Chapter7).Theoriginofriskfactorsforexposureandtheformula-theout
4、breakandthesourceoftheinfectiontionofriskmanagementstrategies.werebothmajorfocusesofattention,thelatterevenmoresooncetheoutbreakinThesearchforthereservoirhumanpopulationswasundercontrol.Wasthisapreviouslyavirulenthumancorona-Epidemiologicalinvestigationsindicatevirusoranotherex
5、ampleofanemergingthattheSARSoutbreakoriginatedinzoonoticinfection?Whatweretheriskfac-GuangdongProvince,China,withtheearli-torsforexposure?Thischapteraddressesestidenti?edcaseinNovember2002.2,3Thethesequestions.searchforthereservoirhasthereforefo-cusedonGuangdongandhascomprisedb
6、othhumanandanimalepidemiologicalTheconceptofreservoirstudies.HumanstudieshavereliedheavilySimplistically,therearetwoplausibleexpla-oncasereportandcaseinterviewdatacol-nationsoftheoriginofSARScoronavirus.ItlectedbytheGuangdongCentreforDiseaseiseitherapreviouslyunidenti?edhumanCo
7、ntrol.Preliminaryanalysisoftheearlycoronaviruswhosevirulenceand/orinfec-Guangdongdatasuggestedanepidemio-tivityincreasedasaresultofgeneticchangelogicassociationbetweenoccupationandoritisananimalcoronavirusthatjumpedinfection,withrestaurantchefsbeingover-toanimmunologicallyna?ve
8、humanhost.represented(ReportoftheFirstWHOMissionConsid
