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1、SUPPLEMENTARTICLESevereAcuteRespiratorySyndromeCoronavirusPathogenesis,DiseaseandVaccinesAnUpdateMarkR.Denison,MDetweenNovember2002andJuly2003,thecoronavirusBackground:Anovelcoronavirushasrecentlybeenidenti?edasBresponsibleforsevereacuterespiratorysyndromethecauseofsevereacuter
2、espiratorysyndrome(SARS-CoV).The(SARS-CoV)infected8500peopleandcaused800abilityofthisfamilyofpositivestrandRNAvirusestomovebetweenspeciesandcauseseverediseaseinhumans,withthedeathsin32countries.Inadditiontothedramaticandseverepotentialforpandemicspread,hasbeencon?rmed.disease
3、associatedwiththisviralinfection,theemergenceMethods:AnunderstandingofthediseaseanditspathogenesisandandrapidtransglobalspreadofSARS-CoVcausedtremen-thegeneticsofcoronavirusinfections,aswellasstrategiestotreatordoussocialandeconomicdisruption.Coronaviruseshadpreventcoronavirusi
4、nfections,areessential.Thehistoryofcorona-previouslybeendemonstratedtomovebetweenspeciesinvirusvaccinesandtheoccurrenceoflaboratory-associatedSARS-cellcultureandwerepredictedtomovereadilybetweenCoVinfectionsunderscoretheneedforstablyattenuatedstrainsofspeciesinnature.Theemergen
5、ceofSARS-CoVhascon-SARS-CoVandothercoronaviruses.?rmedtheselaboratorypredictionsandhasshownthecapac-Results:Rapidprogresshasbeenmadeinunderstandingtheclinicalityforadaptation,diseaseandtransmissionamonghumans.diseaseofSARSinadultsandchildren.Inadults,systemicinfectionTheSARS-Co
6、Vepidemicalsorepresentedperhapsthemostwithclinicalandbiochemicalabnormalities,aswellasrespiratoryextensiveandcoordinatedpublichealthresponseeverinfection,maybetherule.SARSismuchmilderinchildrenyoungermountedagainstahumanpathogen.Itislikelythatthisthan12yearsoldthanitisinadolesc
7、entsandadults.Inchildrenage12yearsandyounger,symptomsaregenerallynonspeci?candpublichealthintervention,alongwithperhapssomelimita-cold-like.NumerousapproachestothedevelopmentofSARS-CoVtionsonthetransmissibilityofthevirus,wereresponsibleforvaccineshavebeenundertaken,andthereisev
8、idencethatantibodiesitscontrolandtheeliminationofdetec
