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1、BRIEFREPORTSevereAcuteRespiratorySyndromelishinganantiviraltreatmentforpatientswithSARS.SARSisprimarilydiagnosedbyaprocessofclinical/epidemiologicalRelatedCoronavirusIsInhibitedexclusion.Despiteimprovementintherecentpast,laboratorybyInterferon-adiagnosis,particularlymoleculardetectionofthevirusbypol
2、y-merasechainreaction,remainsunreliable,especiallyinthe?rstUteStro¨her,1,2AntoninoDiCaro,4YanLi,1,2JamesE.Strong,1FredAoki,2fewdaysofthedisease;inaddition,thetestsarenotyetvali-FrankPlummer,1,2StevenM.Jones,1,3andHeinzFeldmann1,2dated.Serologicanalysisisthoughttobethecon?rmatorylab-1NationalMicrobio
3、logyLaboratory,HealthCanada,andDepartmentsoratorytest,butmostpatientswithSARSdevelopdetectableof2MedicalMicrobiologyand3Immunology,UniversityofManitoba,IgGantibodylevels34weeksaftertheonsetofsymptoms.Winnipeg,Canada;4LaboratoriodiVirologiaPadiglioneBaglivi,IstitutoNazionaleperleMalattieInfettiveL.Sp
4、allanzaniIRCCS,Rome,ItalyThus,differentialdiagnosisremainsaproblemfortheclinicianatthetimeofinitialpresentation,particularlyinindividualswithoutknownexposuretootherpatientswithSARSorhistoryCurrenttreatmentschemesforsevereacuterespiratorysyn-drome(SARS)includebroad-spectrumantibiotics,gluco-oftravelt
5、oaregionwhereSARSisendemic.corticoids,andribavirin.WeevaluatedthesusceptibilityofThecase-fatalityrateof9.5%re?ects,inpart,thelackofantheSARS-relatedcoronavirus(SARSCoV)toribavirinandeffectivespeci?ctreatmentforthisviralinfection.Broad-spec-interferon(IFN)ainvitrobyuseofcytopathiceffect,plaquetrumant
6、ibioticstotreatcommunity-acquiredbacterialpneu-assay,andimmunoblotanalysis.Ribavirindidnotinhibitmonia,glucocorticoids,andribavirinhavebeenadministeredviralgrowthatconcentrationsattainableinhumanserum.topatientswithSARS,buttheiref?cacyisunknown[35].Incontrast,IFN-ashowedaninvitroinhibitoryeffectstar
7、t-Recently,glycyrrhizinhasbeendemonstratedtoinhibittheingatconcentrationsof1000IU/mL.Inconclusion,ribavirinSARS-relatedCoV(SARSCoV)invitro[6].Ribavirinhasbeenaloneisunlikelytobebene?cialintheprophylax
