冠狀病毒Coronavirusl論文-2004 Detection of Severe Acute Respiratory Syndrome-Associated Coronavirus in Pneumocytes of the Lung.pdf

冠狀病毒Coronavirusl論文-2004 Detection of Severe Acute Respiratory Syndrome-Associated Coronavirus in Pneumocytes of the Lung.pdf

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1、MicrobiologyandInfectiousDisease/SARSVIRUSINFECTSPNEUMOCYTESDetectionofSevereAcuteRespiratorySyndrome–AssociatedCoronavirusinPneumocytesoftheLungKuan-ChihChow,PhD,1,5Cheng-HsiangHsiao,MD,2Tze-YiLin,MD,PhD,3Chi-LongChen,MD,PhD,3andShiow-HerChiou,PhD4KeyWords:SARSvirus;Pneumocyte;Insituhybridization;S

2、urfactantDOI:10.1309/C0EDU0RAQBTXBHCEAbstractSevereacuterespiratorysyndrome(SARS)isanacutePreviousreportshaveindicatedthatpatientswithinfectiousdiseasethataffectsprimarilythelowerrespiratorysevereacuterespiratorysyndrome(SARS)–associatedtract,withclinicalmanifestationsofatypicalpneumoniawithcoronavi

3、rusinfectioncoulddevelopatypicaldrycough,persistentfever,progressivedyspnea,and,some-pneumoniawithfulminantpulmonaryedema.However,times,theabruptdeteriorationoflungfunction1-5andthethetargetcellsofSARSviralinfectionhavenotbeenensuingoxygendeprivation–associatedsystemicorganfail-characterizedindetail

4、.Wereportthepathologicures.6,7Atthisstage,thediseasecanbelethal.findingsofthelungin3casesofSARS.ChestPostmortempathologicexaminationshowedthatfulmi-radiographsat2to3weeksofinfectionrevealedannantpulmonaryinterstitialinfiltrate,substantialpulmonaryatypicalpneumoniawithpulmonaryconsolidation,aedema,an

5、dextensivepulmonaryconsolidationwithalve-clinicalcharacteristicofSARSinfection.Thepresenceolitis,formationofhyalinemembrane,andthepresenceofoftheSARSviruswasdeterminedbynestedreversedesquamatedalveolarepithelialcells,whichcorrespondedtranscription–polymerasechainreaction(RT-PCR),wellwiththeprogressi

6、onofclinicalsymptoms,frequentlyandtheinfectedcellswereidentifiedbyinsituwereobserved.4,7AnelegantstudybyKsiazeketal4furtherhybridizationinopen-lungbiopsyandpostmortemdemonstratedthatinadditiontothedispersedalveolarepithe-necropsyspecimens.ExpressionofSARSvirus–encodedlialcells,foamymacrophagesandmul

7、tinucleatedgiantcellsRNAwasdetectedinall3casesbyRT-PCR,andthewereabundantinthedamagedalveolusaswell.InoculationSARSviralsignalwaslocalizedinpneumocytesbywithbronchoalveolarlavagefluidfromthesepatients

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