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1、GASTROENTEROLOGY2003;125:1011–1017RAPIDCOMMUNICATIONSEntericInvolvementofSevereAcuteRespiratorySyndrome–AssociatedCoronavirusInfectionWAIK.LEUNG,*KA–FAITO,?PAULK.S.CHAN,§HENRYL.Y.CHAN,*ALANK.L.WU,*NELSONLEE,*KWOKY.YUEN,andJOSEPHJ.Y.SUNG*Departmentsof*MedicineandT
2、herapeutics,?AnatomicalandCellularPathology,and§Microbiology,TheChineseUniversityofHongKong,PrinceofWalesHospital,Shatin,HongKong;andDepartmentofMicrobiology,UniversityofHongKong,HongKongBackground&Aims:Severeacuterespiratorysyndrome2003.1,2Thediseasethenquicklys
3、preadaroundthe(SARS)isarecentlyemergedinfectionfromanovelworldatanalarmingratein2months.AsofMay31,coronavirus(CoV).Apartfromfeverandrespiratorycom-2003,SARShasbeendescribedin32countriesaffectingplications,gastrointestinalsymptomsarefrequentlyob-8360individualsand
4、causing764deaths.3TheoverallservedinpatientswithSARSbutthesigni?cancere-mortalityforthisillnessisabout16%inHongKong1mainsundetermined.Herein,wedescribetheclinical,andcanbeashighas43%inelderlypatients.4Shortlypathologic,andvirologicfeaturesoftheintestinalin-afterth
5、edescriptionofthisdisease,anovelformofvolvementofthisnewviralinfection.Methods:Aretro-coronavirus,namedtheSARS-CoV,thatdoesnotcloselyspectiveanalysisofthegastrointestinalsymptomsandotherclinicalparametersofthe?rst138patientswithresembleanyofthe3previouslyknowngrou
6、psofcoro-con?rmedSARSadmittedforamajoroutbreakinHongnaviruseswasidenti?edtobethecausativeagent.5,6ThisKonginMarch2003wasperformed.Intestinalspeci-viruscanbedetectedbycultureandpolymerasechainmenswereobtainedbycolonoscopyorpostmortemreaction(PCR)frommostpatientswit
7、hSARS,andspe-examinationtodetectthepresenceofcoronavirusbyci?cantibodiesagainstthisnewviruscanalsobeshownelectronmicroscopy,virusculture,andreverse-transcrip-intheinfectedhost.Furthermore,amonkeyinoculationtionpolymerasechainreaction.Results:Amongtheseexperimentpr
8、oducessimilardiseaseasinhumans,ful-138patientswithSARS,28(20.3%)presentedwith?llingtheKoch’spostulate.7waterydiarrheaandupto38.4%ofpatientshadsymp-Theco
