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1、HidekiHasegawaORCIDiD:0000-0002-6558-2297NoriyoNagataORCIDiD:0000-0001-9147-1438Goldnanoparticle-adjuvantedSproteininducesastrongantigen-specificIgGresponseagainstsevereacuterespiratorysyndrome-relatedcoronavirusinfection,butfailstoinduceprotectiveantibodiesandlimiteosinophilicinfiltrati
2、oninlungsShorttitle:AsubunitvaccineagainstcoronavirusSubjectsections:Vaccinesandantiviralagents1,2133#aHanakoSekimukai,NaokoIwata-Yoshikawa,ShuetsuFukushi,HidekiTani,1114#bMichiyoKataoka,TadakiSuzuki,HidekiHasegawa,KenichiNiikura,21KatsuhikoArai,andNoriyoNagata*1DepartmentofPathology,Nat
3、ionalInstituteofInfectiousDiseases,Musashimurayama,Tokyo,JapanThisarticlehasbeenacceptedforpublicationandundergonefullpeerreviewbuthasnotbeenthroughthecopyediting,typesetting,paginationandproofreadingAcceptedArticleprocess,whichmayleadtodifferencesbetweenthisversionandtheVersionofRecord.
4、Pleasecitethisarticleasdoi:10.1111/1348-0421.12754.Thisarticleisprotectedbycopyright.Allrightsreserved.2DepartmentofTissuePhysiology,FacultyofAgriculture,TokyoUniversityofAgricultureandTechnology,Fuchu,Tokyo,Japan3DepartmentofVirologyI,NationalInstituteofInfectiousDiseases,Musashimurayam
5、a,Tokyo,Japan4ResearchInstituteforElectronicScience,HokkaidoUniversity,Sapporo,Hokkaido,Japan#aCurrentaddress:DepartmentofVirology,GraduateSchoolofMedicineandPharmaceuticalSciences,UniversityofToyama,Toyama,Toyama,Japan#bCurrentaddress:DepartmentofAppliedChemistry,FacultyofFundamentalEng
6、ineering,NipponInstituteofTechnology,Minamisaitama,Saitama,Japan*CorrespondingauthorNoriyoNAGATA,DVM,PhDDepartmentofPathologyNationalInstituteofInfectiousDiseasesAcceptedArticleMusashimurayama,Tokyo,JapanE-mail:nnagata@nih.go.jp;Thisarticleisprotectedbycopyright.Allrightsreserved.Tel:+81
7、-42-561-0771(ext3361)Fax:+81-42-561-6572AbstractThespike(S)proteinofcoronavirus,whichbindstocellularreceptorsandmediatesmembranefusionforcellentry,isacandidatevaccinetargetforblockingcoronavirusinfection.However,someanimalstudieshavesuggestedthatinadequateimmunizationagai
