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1、VECTOR-BORNEANDZOONOTICDISEASESVolume14,Number12,2014aMaryAnnLiebert,Inc.DOI:10.1089/vbz.2014.1637MolecularSurveyofRNAVirusesinHungarianBats:DiscoveringNovelAstroviruses,Coronaviruses,andCaliciviruses1,21,23,745Ga′borKemenesi,BiankaDallos,Tama′sGo¨rfo¨l,
2、Sa′ndorBoldogh,Pe′terEsto′k,21,21,21,21,2Korne′liaKurucz,AnnaKutas,FanniFo¨ldes,Miklo′sOldal,Vikto′riaNe′meth,671,2VitoMartella,Krisztia′nBa′nyai,andFerencJakabAbstractBackground:Bat-bornevirusesposeapotentialrisktohumanhealthandarethefocusofincreasingsc
3、ienti?cinterest.Tostartgaininginformationaboutbat-transmittedvirusesinHungary,wetestedmultiplebatspeciesforseveralvirusgroupsbetween2012and2013.MaterialsandMethods:FecalsampleswerecollectedfrombatsacrossHungary.Weperformedgroup-speci?cRT-PCRscreeningfora
4、stro-,calici-,corona-,lyssa-,othoreo-,paramyxo-,androtaviruses.Positivesampleswereselectedandsequencedforfurtherphylogeneticanalyses.Results:Atotalof447fecalsamples,representing24Europeanbatspeciesweretested.Novelstrainsofastroviruses,coronaviruses,andca
5、licivirusesweredetectedandanalyzedphylogenetically.Outofthe447testedsamples,40(9%)batswerepositiveforatleastonevirus.Bat-transmittedastroviruses(BtAstV)weredetectedineightspecieswitha6.93%detectionrate(95%con?denceinterval[CI]4.854,9.571).Coronaviruses(B
6、tCoV)weredetectedinsevenbatspecieswithadetectionrateof1.79%(95%CI0.849,3.348),whereasnovelcaliciviruses(BtCalV)weredetectedinthreebatspecieswithadetectionrateof0.67%(95%CI0.189,1.780).Phylogeneticanalysesrevealedagreatdiversityamongastrovirusstrains,wher
7、eastheHungarianBtCoVstrainsclusteredtogetherwithbothalpha-andbetacoronavirusstrainsfromotherEuropeancountries.Oneofthemostintriguing?ndingsofourinvestigationisthediscoveryofnovelBtCalVsinEurope.TheHungarianBtCalVdidnotclusterwithanyofthecalcivirusgenerai
8、denti?edinthefamilysofar.Conclusions:Wehavesuccessfullycon?rmedBtCoVsinnumerousbatspecies.Furthermore,wehavede-Vector-BorneandZoonoticDiseases2014.14:846-855.scribednewbatspeciesharboringBtAstVsinEuropeandfoundnewspeciesof
