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1、米力農(nóng)治療老年人慢性肺心病心衰50例療效觀察【摘要】目的觀察米力農(nóng)對(duì)老年人慢性肺心病心衰的療效，尋求糾止老年人慢性肺心病心衰的合理用藥。方法50例患者為米力農(nóng)治療紐.，在綜合治療的基礎(chǔ)上以米力農(nóng)首劑負(fù)荷量50ug/(kg?min)，緩慢靜注10min,再以0.5ug/(kg?min)靜滴，時(shí)間4h,每日1次,7d為1療程；48例患者為對(duì)照紐.，在綜合治療基礎(chǔ)上加多巴酚丁胺20?40mg+5%葡萄糖250ml,以2.5Ug/(kg?min)靜滴,每日1次,7d為1療程。結(jié)果治療組顯效率44%(22/50),有效率52%(26/50),總有效率96%；對(duì)照組顯效
2、率35.4%(17/48),做率45.8%(22/48),總有效率81.1%。治療紐療效明顯優(yōu)于對(duì)照紐(PvO.Ol)。結(jié)論老年慢性肺心病心衰洋地黃類強(qiáng)心劑不但療效差，口易導(dǎo)致中毒，選擇米力農(nóng)既發(fā)揮止性肌力作用，又可擴(kuò)張血管減輕心臟負(fù)荷，療效肯定、安全?！娟P(guān)鍵詞】老年人慢性肺心病治療米力農(nóng)MilrinonetherapyinheartfailureoftheagedchroniccorpulmonaleWANGYibing,XIAOLi,LIULimin,ZHANGTianmin.DepartmentofRespiratoryMedicine,Affilia
3、tedHospitalofWuhanUnivestyScieneandTechnology,Wuhan43CX)64,China[Abstract]ObjectiveToobservetheeffectofmilrinoneinthetreatmentofheartfailureoftheagedchroniccorpulmonale?MethodsMilrinonegroupwasenrolled(50cases).Onthebasisofcomprehensivetreatment,thefirstloadingdoseofMilrinonewas50&
4、mu;g/(kg.min),followedby0.5μg/(kg.min)IVdriptor4h,oncedaily.Onetherapeuticcoursewas7d.Controlledgroupansistedof48cases,inadditiontocomprehensivetherapy,DobutamineHC120?40nig+5%glucose250nilwasaddedindosageof2.5μg/(kg.min)IVdrip,oncedailyfor7dasatherapeuticcourse.ResultsInther
5、apeuticgroup,theexcellentlyeffectivecaseswerein22/50cases(44%),thefairlyeffectivecaseswerein26/50cases(52%),thetotalimpororementratewas96%.Incontrolgroup,theexcellentlyeffectivecaseswerein17/48cases(35.4%),thefairlyeffectivecaseswerein22/48cases(45.8%),thetotalimprovementratewas81.
6、1%.Theimprovementrateintherapeuticgroupwassignificantlyhigherthanthatofcontrolgroup,(P<0.01)?ConclusionsThetherapeuticeffectofdigitaliscardiacglycosidesintreatmentofheartfailureoftheagedchroniccorpulmonaleareusuallyunsatisfactoryandsometimesitcanresultindigitalisintoxication.Choice
7、ofMilrinonenotonlyhasthepositiveinotropicofcardiacmuscle,butalsoitcandilatethebloodvesselsinordertolessentheheartload.Milrinoneisasafedrugandithasgoodeffectforheartfailureofcorpulmonale?【Keywords]aged：chroniccorpulmonale；treatment；milrinone米力農(nóng)(milrinone)是-?種新興的非洋地黃類的止性肌力藥物[1],它的臨床療
8、效已得到充分的肯定，但是萇致室性心律失常、加速基礎(chǔ)心
