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1、·藥物研究·中l(wèi)虱茄2015年6月20日第24卷第l2期DrugReseerchChinaPharmaceuticsVo1.24,No.12,June20,2015甲磺酸倍他司汀與尼莫地平治療神經(jīng)性耳鳴療效對比侯莉,王琦(四川省德陽市婦幼保健院,四川德陽618000)摘要:目的觀察并對比甲磺酸倍他司汀與尼莫地平治療神經(jīng)性耳嗚的臨床療效。方法將醫(yī)院2013年12月至2014年12月收治的68例耳鳴患者分為對照組和治療組,各34例,對照組患者采用尼莫地平治療,治療組患者采用甲磺酸倍他司汀治療。結果治療后,兩組患者耳鳴癥狀均得到有效改善,且治
2、療組改善更顯著(P<0.05);治療組患者耳鳴癥狀評分顯著低于對照組(P<0.05);治療組患者瞬態(tài)誘發(fā)性耳聲發(fā)射(TEOAE)有效引出率顯著高于對照組(P<0.05);兩組患者在治療過程中均出現(xiàn)了不良反應,但治療組不良反應發(fā)生率明顯低于對照組(P<0.05)。結論甲磺酸倍他司汀治療神經(jīng)性耳鳴的,臨床療效比尼莫地平更確切,能促進耳蝸功能的恢復,且安全性高,值得臨床推廣。關鍵詞:甲磺酸倍他司?。簧窠?jīng)性耳鳴;瞬態(tài)誘發(fā)性耳聲發(fā)射中圖分類號:11969.4;R9724-.4文獻標識碼:A文章編號:1006—4931(2015)12—0042—0
3、2EficacyofBetahistineMesilateandNimodipineforTreatingNervousTinnitusin34CasesHouLi,WangQi(DeyangMunicipalMaternalandChildHealthCareHospital,Deyang,Sichuan,China618000)Abstract:ObjectiveToobservetheclinicalefficacyofbetahistinemesilateandnimodipineinthetreatmentofnervoust
4、inni—tus.Methods68patientswithnervoustinnitusinthehospitalfromDecember2013toDecember2014weredividedintothetreatmentgroupandthecontrolgroup,34caseseach.Thecontrolgroupwastreatedwithnimodipine,whilethetreatmentgroupusedthebetahis—finemesilatetherapy.ResultsThetinnitussympt
5、omaftertreatmentinthetwogroupswaseffectivelyimproved,moreovertheimprove—mentofthetreatmentgroupwasmoresignificant(P<0.05):thescoresoftinnitussymptominthetreatmentgroupweresignificantlylowerthanthoseinthecontrolgroup(P<0.05):theeffectiveelicitationrateoftransientevokedoto
6、acousticemission(TEOAE)inthetreatmentgroupwassignificantlyhigherthanthatinthecontrolgroup;theadversereactionsappearedduringthetreatmentprocessinthetwogroups,buttheoccu~encerateofadversereactioninthetreatmentgroupwassignificantlylowerthanthatinthecontrolgroup.thedifferenc
7、ewasstatisticallysignificant(P<0.05).ConclusionBetahistinemesilatehasdefiniteclinicaleffectfortreatingnervoustinnitus,canpromotetherecoveryofcochlearfunctionwithhighsafetyanddeservestobeclinicallypromoted.Keywords:betahistinemesilate;tinnitus;transientevokedotoacousticem
8、ission神經(jīng)性耳嗚是由于耳神經(jīng)受損后導致的聽覺系統(tǒng)感音障礙,療神經(jīng)性耳鳴的臨床療效、瞬態(tài)誘發(fā)性耳聲發(fā)射(TEOAE)等指標病變部位在耳蝸或耳蝸后,臨床表現(xiàn)主要為患者的頭部或耳部感的影響進行了對比研究,現(xiàn)