血脂康預(yù)處理對(duì)心肌缺血再灌注大鼠炎癥因子影響的論文

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1、血脂康預(yù)處理對(duì)心肌缺血再灌注大鼠炎癥因子影響的論文血脂康預(yù)處理對(duì)心肌缺血再灌注大鼠炎癥因子影響【關(guān)鍵詞】心肌;再灌注損傷;炎癥;白細(xì)胞介素類;大鼠,spraguedain，然后再通60min;假手術(shù)組只開胸不結(jié)扎冠狀動(dòng)脈，空白組不做任何處理。采集大鼠腹主動(dòng)脈血，分離血清，檢測(cè)白細(xì)胞介素(il)1β、il4、il8、腫瘤壞死因子(tnfα)、肌酸激酶同工酶(ckmb)、肌鈣蛋白i(ctni)含量，并處死動(dòng)物取出心臟，計(jì)算心肌梗死面積。結(jié)果缺血再灌注組il1β、il4、il8、tnfα、c

2、kmb和ctni血清含量均明顯高于空白組和假手術(shù)組(f=48.72～351.07,q=0.25～41.65,p<0.01);而血脂康預(yù)處理組上述指標(biāo)除il4外均低于缺血再灌注損傷組(q=0.35～32.65,p<0.05)，且血脂康預(yù)處理組大鼠心肌梗死面積小于缺血再灌注損傷組(f=231.26,q=17.21,p<0.05)。.結(jié)論血脂康能抑制促炎因子il1β、il8、tnfα的生成，并增加抗炎因子il4生成，減輕心肌缺血再灌注損傷，對(duì)缺血再灌注損傷具有明顯的保護(hù)作用?！娟P(guān)鍵

3、詞】心肌;再灌注損傷;炎癥;白細(xì)胞介素類;大鼠,spraguedaentoninflammatoryfactorofmyocardialischemiareperfusioninjuryinratsniemaoxiao,zhangxuejuan,tenglei(departmentofcardiology,theaffiliatedhospitalofqingdaouniversitymedicalcollege,qingdao266003,china);[abstract]objectiveto

4、observetheeffectsofxuezhikangcapsulesoninflammatoryfactorofmyocardialischemiareperfusioninjury(miri)inratsandexploreitspossiblemechanismofaction.methodsthirtytizedtofourgroups:blankgroup,shamoperationgroup,mirigroupandxuezhikangpretreatmentgroup.therat

5、sinxuezhikanggroupeamountofsaline,for7days.thoseinmiriandxuezhikangpretreatmentgroupsunderyandtheleftanteriordescendingbranchofcoronaryarteryinutesandthenrecanalizedfor60minutes;thoseinshamoperationgroupreceivedonlythoracotomyanagementplestheabdominalaor

6、ta,andtheserumseparated.theinterleukin1β(il1β),il4,il8,tumornecrosisfactoralpha(tnfα),creatinekinasemb(ckmb),andtroponiniyocardialinfarction(mi)irigroup,theserumlevelsofil1β,il4,il8,tnfα,ckmb,andctnialgroupandshamoperationgroup(f=48.72-351.07

7、，q=0.25-41.65，p<0.01),etersinthepretreatmentgroupirigroup,exceptil4(f=48.72-351,q=0.35-32.65,p<0.05).theareaofmiinxuezhikangpretreatmentgroupallerthanthoseinthemiri(f=231.26，q=17.21，p<0.05).conclusionxuezhikangcaninhibittheproductionofproinflamm

8、atoryfactors,suchasil1β,il8andtnfα,andincreaseantiinflammatoryil4,thuslesseningischemiareperfusioninflammatoryreactionandinjury.　　[keyyocardium;reperfusioninjury;inflammation;interleukins;rats,spraguedagcoa)