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1、目錄丙型肝炎治療藥物研究與設計………………………………………………………3以生命周期劃分HCV治療藥物整理………………………………………4HCV的結構………………...……………………………………………4HCV生命周期………………………………………………………...…5以生命周期劃分HCV治療藥物整理…………………………..............6總結和展望………………………...…………………………..……….13基于NS5A抑制劑的創(chuàng)新藥物設計………………………………………14前言................
2、..........................................................................................14NS5A靶點...............................................................................................14NS5A抑制劑研究進展........................................................
3、...................15BMS-790052(daclatasvir)研究................................................................20創(chuàng)新藥物設計..........................................................................................24參考文獻................................................
4、..................................................26TLR-7激動劑研究與設計………………………………………………….29目前已開發(fā)的激動劑..............................................................................29咪唑喹啉胺（imidazoquinolineamine）類..................................291-取代吡唑啉酮（1-Substitute
5、dPyrazolo(3,4-C)Ring）類......318-氧-去氮嘌呤類/咪唑并吡啶酮類............................................328-羥基腺嘌呤（8-Hydroxyadenine）類......................................36擴環(huán)8-羥基腺嘌呤類..................................................................57艾沙托立賓（Isatoribine）衍生物類...
6、.......................................61BitriazolylAcyclonucleoside類...................................................64三氮唑類（Triazole）.................................................................65嘧啶類（Pyrimidine）............................................
7、.....................668-SubstituedBenzoazepines類....................................................68Aminodiazepine類.......................................................................69未來可能的變動空間..............................................................
8、................70創(chuàng)新藥物設計..........................................................................................71參考文獻..............................................
