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1、目錄丙型肝炎治療藥物研究與設(shè)計(jì)………………………………………………………3以生命周期劃分HCV治療藥物整理………………………………………4HCV的結(jié)構(gòu)………………...……………………………………………4HCV生命周期………………………………………………………...…5以生命周期劃分HCV治療藥物整理…………………………..............6總結(jié)和展望………………………...…………………………..……….13基于NS5A抑制劑的創(chuàng)新藥物設(shè)計(jì)………………………………………14前言................
2、..........................................................................................14NS5A靶點(diǎn)...............................................................................................14NS5A抑制劑研究進(jìn)展........................................................
3、...................15BMS-790052(daclatasvir)研究................................................................20創(chuàng)新藥物設(shè)計(jì)..........................................................................................24參考文獻(xiàn)................................................
4、..................................................26TLR-7激動(dòng)劑研究與設(shè)計(jì)………………………………………………….29目前已開(kāi)發(fā)的激動(dòng)劑..............................................................................29咪唑喹啉胺（imidazoquinolineamine）類..................................291-取代吡唑啉酮（1-Substitute
5、dPyrazolo(3,4-C)Ring）類......318-氧-去氮嘌呤類/咪唑并吡啶酮類............................................328-羥基腺嘌呤（8-Hydroxyadenine）類......................................36擴(kuò)環(huán)8-羥基腺嘌呤類..................................................................57艾沙托立賓（Isatoribine）衍生物類...
6、.......................................61BitriazolylAcyclonucleoside類...................................................64三氮唑類（Triazole）.................................................................65嘧啶類（Pyrimidine）............................................
7、.....................668-SubstituedBenzoazepines類....................................................68Aminodiazepine類.......................................................................69未來(lái)可能的變動(dòng)空間..............................................................
8、................70創(chuàng)新藥物設(shè)計(jì)..........................................................................................71參考文獻(xiàn)..............................................
