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1、N末端B型利鈉肽原檢測對急性呼吸困難鑒別診斷的臨床價仲臘春(江蘇省灌南縣人民醫(yī)院檢驗科江蘇連云港222500)【摘要】目的:探討N末端B型利鈉肽原(NT-proBNP)檢測對急性呼吸困難的鑒別診斷價值。方法:將328例急性呼吸困難患者,根據臨床診斷分為急性充血性心力衰竭組(急性心衰組)176例及非心衰組152例,比較兩組患者初入院時的NT-proBNP水平,評價其對急性呼吸困難鑒別診斷的價值。結果:急性心衰組及非心衰組NT-proBNP濃度分別為3184.4±1638.3pg/mL和388.6±
2、154.7pg/mL,兩組比較差異具有顯著性意義(P<0.01)。以NT-proBNP≥1500pg/mL為心力衰竭陽性診斷[1],診斷急性充血性心力衰竭的靈敏度為92.0%,特異性為90.1%,陽性預測值為91.5%,陰性預測值為90.7%,診斷效率達91.2%。結論:急診常規(guī)檢測NT-proBNP有利于對急性呼吸困難患者做出快速診斷,有助于鑒別急性呼吸困難是否為急性充血性心力衰竭所致?!娟P鍵詞】N末端B型利鈉肽原;急性呼吸困難;心力衰竭;鑒別診斷【屮圖分類號】R446【文獻標識碼】A【文章編號】1007-8231
3、(2015)11-0017-02DetectionofNterminalBtypenatriureticpeptideontheclinicalvalueofdifferentialdiagnosisofacutedyspneaZhongLachun.GuannanCountypeople’sHospitalofJiangsuProvince.225OO.China【Abstract】ObjectiveStudyondetectionofNterminalBtypenatriureticpeptideontheclinic
4、alvalueofdifferentialdiagnosisofacutedyspnea.Methods328casesofacutedyspneaweredividedinto176caseswithacutecongestiveheartfailureand152caseswithnonheartfailuregroupaccordingtotheclinicaldiagnosis,TheNT-BNPleveloftwogroupsofpatientswerecompared,andthevalueofthediffe
5、rentialdiagnosisofacutedyspneawasevaluated.ResultsNT-BNPconcentrationsinacuteheartfailuregroupandnonheartfailuregroupweresignificantlydifferentbetween3184.4±1638.3pg/mLand388.6±154.7pg/mLtwogroups(P<0.01).NT-proBNP≥1500pg/mLforheartfailurediagnosi
6、s,thesensitivityofdiagnosisofacutecongestiveheartfailurewas92.0%,thespecificitywas90.1%,thepositivepredictivevaluewas91.5%,thenegativepredictivevaluewas90.7%,thediagnosticefficiencywas91.2%.ConclusionRoutinedetectionofNT-proBNPishelpfulformakingrapiddiagnosisofacu
7、tedyspnea,anditcanbehelpfultoidentifyacuterespiratorydifficultiesandwhetheritiscausedbyacutecongestiveheartfailure.【Keywords]NterminalBtypenatriureticpeptide;Acutedyspnea;Heartfailure;Differentialdiagnosis心力衰竭(心衰)是各種心血管疾患的終末階段,奮很高的發(fā)病率及病死率。因此,對于急性心衰患者,早期診斷及吋對癥治療具有非
8、常重要的意義,心衰的臨床診斷主要依據臨床癥狀和影像學檢査,但這些依據常缺乏特異性,與其它肺部疾病難以區(qū)分。N末端B型利鈉肽原(NT-proBNP)是在心室壁受牽拉吋心室分泌的一種激素,它以激素原的形式分泌,然后等比例分解成腦尿鈉肽(BNP)和NT-proBNP,NT-proBNP代謝速度較BNP慢,濃度