急性白血病患者血漿vegf測定及其臨床意義

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1、維普資訊http://www.cqvip.coml臨床血液學雜志2004年1月第17卷第1期·9·急性白血病患者血漿VEGF測定及其臨床意義郭宗明謝兆霞秦憶譚達人[摘要]目的：探討急性白血病(AL)患者血漿血管內(nèi)皮細胞生長因子(VEGF)含量變化與I臨床病情的關系。方法：用雙抗體夾心酶聯(lián)免疫吸附法(ELISA)檢測54例AI患者血漿VEGF含量，同時檢測骨髓涂片有核細胞中原始及幼稚白細胞數(shù)。結果：①AI患者血漿VEGF含量[(64．76±34．86)ng／L]明顯高于對照組r(33．13±l1．97)ng／[

2、](PO．05)。結論：①AL患者血漿VEGF含量升高與白血病細胞生長、增殖有關；②AI患者血

3、漿VEGF含量與臨床病情變化密切相關，可作為了解病情、觀察療效、判斷預后的指標之一。[關鍵詞]白血病，急性；血管內(nèi)皮細胞生長因子；預后[中圖分類號]R733．71[文獻標識碼]A[文章編號]1004—2806(2004)01—0009—03TheclinicalsignificanceofdetectingplasmaVEGFcOncentratiOninacuteleukemiaGUOZongrningXIEZhaoxiaQJNTANDaren(DepartmentofHematology，XiangyaH

4、ospitalofZhongnanUniversity，Changsha410008，China)AbstractObjective：ToinvestigatetherelationshipsbetweenplasmaVEGFconcentrationandclinicalcondi—tioninacuteleukemia．Method：TheplasmaVEGFconcentrationof54patientswithacuteleukemiawasdetectedbyELISAandthenumberso

5、ftheblastcellofwhitebloodcellswerecountedwithinnucleatedcellsinbonemarrow．Result：①TheplasmaVEGFconcentrationoftheAIgroupwassignificantlyhigherthanthatofcontrol(64．76±34．86vs33．13±11．97ng／I，P<0．O1)andtherewaslinearcorrelationbetweentheplasmaVEGFconcentration

6、andtheratiooftheblastcellofwhitebloodcellsinbonemarrow(r：0．437，P<0．01)．②TheplasmaVEGFconcentrationoftheuntreatedgroupwassignificantlyhigherthanthatofremissiongroup(76．01±40．18vs42．07±17．75ng／L，P<0．01)andtheplasmaVEGFconcentrationoftherefractory／relapsedgrou

7、pwasincreased(78．21±31．77ng／L)。whichwassignificantlyhigherthanthatofremissiongroup(P<0．01)。butnosignifi—cancebetweentherefractory／relapsedgroupandtheuntreatedgroup(P>O．05)．Conclusion：①VEGFmayplayaroleinthegrowthandprliferationofleukemiacel1．②TheplasmaVEGFco

8、ncentrationissignificantlyassociatedwithclinicalcondition，soitcanbeoneoftheindicatorsforlearningclinicalfeaturesandpredictingprognosisofALpatients．KeywordsIeukemia，acute；Vascularendotheliagrowthfactor：