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1、?242?湖北醫(yī)藥學(xué)院學(xué)報(bào)(JHBUM)2013年6月,32(3)doi:10.7543/j.issn.1006-9674.2013.03.014??????????????????????????????????????????引?用?本?文?格式?:康??健?,陳??悅,?楊東?亮?,等?.?急性?肝?衰?竭病?因?與?預(yù)后?分?析?[J]?.湖?北?醫(yī)?藥學(xué)?院?學(xué)?報(bào),?201?3,?32(?3)?:24?2-?24?4.??急性肝衰竭病因與預(yù)后分析1,??1,???2,???1??1(
2、湖北醫(yī)藥學(xué)院附屬太和醫(yī)院感染科,湖北十堰442000;2華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬協(xié)和醫(yī)院感染科,湖北武漢430030)[摘要]目的:根據(jù)最新指南回顧性分析急性肝衰竭(acuteliverfailure,ALF)病因構(gòu)成與預(yù)后?方法:通過(guò)檢索及病例查閱共確定61名ALF患者,分析其病因?實(shí)驗(yàn)室指標(biāo)及預(yù)后?結(jié)果:乙型肝炎病毒(hepatitisBvirus,HBV)感染為ALF的主要病因,占85.2%?死亡組與存活組比較,除丙氨酸氨基轉(zhuǎn)移酶(alanineaminotransferase,ALT)
3、?肌酐(creatinine,Cr)外,其他指標(biāo)如年齡?白蛋白(albumin,Alb)?總膽紅素(totalbilirubin,TBil)?血清鈉?凝血酶原時(shí)間(prothrombintime,PT)?國(guó)際標(biāo)準(zhǔn)化比值(internationalnormali?edratio,INR)組間差異均有統(tǒng)計(jì)學(xué)意義(?<0.05)?結(jié)論:HBV感染是湖北省及周邊地區(qū)ALF的主要發(fā)病原因?年齡?白蛋白?總膽紅素?血清鈉?凝血酶原時(shí)間?國(guó)際標(biāo)準(zhǔn)化比值等與ALF預(yù)后密切相關(guān)?[關(guān)鍵詞]急性肝衰竭;病因?qū)W;預(yù)后
4、112?????????E?????????????????????????????????A????L????F??????KANGJian,CHENYue,YANGDong-liang,112MENGZhong-ji(D???????????I?????????D???????,?????H???????,H????????????????M???????,??????,H????442000;?????H???????????????M??????C??????,H????????????
5、???????????????????????????,?????,H????440000,C????)A???????:?????????Toreviewtheetiologicfactorsandprognosisinpatientswithacuteliverfailureretrospectivel?accord-ingtothenewstandardofALF.???????Atotalof61patientswithALFwereidentified,andthenthecauses
6、,laborator?profilesandprognosiswereinvestigated.???????Themostcommonetiolog?ofALFinHubeiprovinceandneighboringre-gionswasHBVinfectionaccountedfor85.2%.Theindexesofage,Alb,totalbilirubin,serumsodiumlevel,PTandINRex-cludingALTandCrweresignificantl?diff
7、erentbetweendeathgroupandsurvivalgroup(?<0.05).??????????Themostcommonetiolog?ofALFwasHBVinfectioninHubeiprovinceandneighboringregions.Theage,albumin,totalbilirubin,se-rumsodiumlevel,prothrombintimeandinternationalnormali?edratioareimportantprognosti
8、cfactors.K???????:Acuteliverfailure;Etiolog?;Prognosis[1]肝衰竭是多種原因引起的嚴(yán)重肝臟損害,導(dǎo)致及肝毒性物質(zhì)(如化學(xué)試劑和酒精等)?為進(jìn)一其解毒?排泄?合成和生物轉(zhuǎn)化等功能障礙或失代步了解ALF的病因構(gòu)成及預(yù)后情況,本研究對(duì)2005償,出現(xiàn)以黃疸?腹水和肝性腦病(hepaticencepha-年1月-2010年5月在華中科技大學(xué)同濟(jì)醫(yī)學(xué)院lopath?,HE)等凝血機(jī)制障礙為主要表現(xiàn)的一組臨附屬同濟(jì)醫(yī)院感染科住院的肝衰竭患者進(jìn)行了回顧[1