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1、Q開關(guān)Nd:YAG激光聯(lián)合重組人表皮生長因子治療顴部褐青色痣療效觀察［摘要］目的：評(píng)價(jià)Q開關(guān)Nd:YAG激光聯(lián)合重組人表皮生長因子(recombinanthumanepidermalgrowthfactor,rhEGF)在治療顴部褐青色痣（naevusfuscocaeruleuszygomaticusNFZ）過程中對(duì)減輕色素沉著，縮短療程的作用。方法：對(duì)2004年12月～2007年12月采用Q開關(guān)Nd:YAG激光治愈的52例顴部褐青色痣患者的臨床資料進(jìn)行回顧性分析，治療組27例（治療后外涂重組人表皮生長因子），
2、對(duì)照組25例（治療后待自然愈合），比較其治療間隔時(shí)間、療程的長短。結(jié)果：治療組與對(duì)照組平均治療間隔時(shí)間分別為74.59天及105.24天，平均療程分別為453.37天及651.28天，兩組差異有統(tǒng)計(jì)學(xué)意義（P＜0.05）。結(jié)論：Q開關(guān)Nd:YAG激光聯(lián)合重組人表皮生長因子治療顴部褐青色痣色素沉著輕、療程較短，值得臨床推廣。［關(guān)鍵詞］Q開關(guān)Nd:YAG激光；顴部褐青色痣；重組人表皮生長因子；療效[中圖分類號(hào)]R758.51[文獻(xiàn)標(biāo)識(shí)碼]A[文章編號(hào)]1008-6455（2008）06-0892-03Theobse
3、rvationoftheraperticeffectofnaevusfuscocaeruleuszygomaticustreatedbyQ-switched9Nd:YAGlaserassociatedwithrecombinanthumanepidermalgrowthfactorYANGHai-bo，LIDa-tie,ANLi-sha,WENYang,TANGZheng-xi(DepartmentofCosmeticLaser,theCosmeticHospitaloftheAffiliatedHospita
4、lofZunyiMedicalCollege,Zunyi563003,Guizhou,China)Abstract:ObjectiveToevaluatethetherapeuticeffectofnaevusfuscocaeruleuszygomaticustreatedbyusingQ-switchedNd:YAGlaserassociatedwithrecombinanthumanepidermalgrowthfactortolessenpigmentationanddecurtatecourseoftr
5、eatment.MethodsToreviewandanalysizetheclinicaldataof52patientswithNFZwhichhavebeenrecoveredinthepastyearsrangedfrom2004.12to2007.12.Allthecasesweredividedintotwogroups:thetherapicgroupwith27caseswereappliedrhEGFafterthetreatmentandthecontrolgroupwith25casesw
6、erehealedradomlytocompareintervaltimeandcourseoftreatment.ResultsTheaverageintervaltimeofthetherapicgroupandthecontrolgroupwasrespectively74.59daysand105.24days,9andtheaveragetimeoftherapyofbothgroupswasrespectively453.37daysand651.28days.Thedifferenceofthem
7、wasstatisticalsignificance（P＜0.05）.ConclusionThetherapicmethodofNFZbyQ-switchedNd:YAGlaserassociatedwithrhEGF.isworthgeneralizationinclinicbecauseoflesspigmentationandshortertimeoftherapyKeywords:Q-switchedNd:YAGlaser;naevusfuscocaeruleuszygomaticus;recombin
8、anthumanepidermalgrowthfactor;therapeuticeffect顴部褐青色痣（naevusfuscocaeruleuszygomaticus，NFZ）是對(duì)稱分布于雙側(cè)顴部、顳部、上眼瞼外側(cè)，呈青褐色、棕褐色及黃褐色群集而不融合的圓形或卵圓形的色素性皮膚病。傳統(tǒng)的治療方法，如冷凍、磨削、化學(xué)剝脫術(shù)等療效不佳。目前認(rèn)為應(yīng)用Q開關(guān)Nd:YAG激光治療NFZ是一種
