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1、常用軟膏劑的制備???????????????????????????????????????????0542327仝贇??????????????????????????????????????Preparationofointments???Ointmentsaresemi-solidpreparationsmadeofmedicamentsandsuitablebases,whichareintendedforexternalapplicationtotheskin.Ointmentbasesrecogni
2、zedforuseasvehiclesdistinguishedintothreegeneralclasses:theoleaginousbases,theemulsionbases,andthewater–solublebases.???Therearethreegeneralmethods:themethodofgrindingandmixing,themethodofmeltingandmixing,themethodofemulsification.???Ophthalmicointmentsareoin
3、tmentsforapplicationtotheeyewhosebasesgeneralincludeliquidparaffin,Vaselineandwoolfat.Specialprecautionsmustbetakeninthepreparationofophthalmicointments.Theyaremanufacturedfromsterilizedingredientsunderrigidlyasepticconditions.Theointmentbasethatisselectedmus
4、tbewithoutanyirritationtoeye.?Equipments:evaporating,waterbath,electricfurnace,analyticalbalance,thermometer,microscopeetc.?Materials:Stearicacid,glycerolmonostearate,Vaseline,glycerol,liquidparaffin,triethanolamine,calciumhydroxide,CMC-Na,span80,nonoxynol-10
5、,distilledwateretc.Procedures:?1.??????O/Wemulsionbase?FormulationStearicacid????????????4.8gGlycerolmonostearate???1.4gLiquidparaffin??????????2.4gVaseline???????????????0.4g??????TokeepwaterWoolfat???????????????2.0gTriethanolamine?????????0.16gDistilledwat
6、eraddupto??40.0g?Preparation:???Addstearicacid,glycerolmonostearate,liquidparaffin,Vaselineandwoolfatintoevaporatingdish,whichthemixtureisusedasoilphase.Addtriethanolamineanddistilledwaterintobeaker,whichthesolutionisusedasawaterphase.Thetwocontainersareheate
7、dto80°Cinwaterbathandkeptuntilmeltingcompletely.Pouroilphaseintowaterphaseslowly,andstirthemfully.Coolatroomtemperature,thentheO/Wemulsionbasecanbegot.2.???????W/Oemulsionbase?Formulation:Glycerolmonostearate?????????0.85gBeeswax????????????????????5.25gParaf
8、fin?????????????????????3.75gStearicacid??????????????????0.625gLiquidparaffin????????????????20.5gVaseline?????????????????????3.35g?????????????????????TokeepwaterSpan80????????????????
