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1、Parkinson’sDiseasewileyBackgroundParkinson’sdiseaseisaprogressivedegenerationdisorderofthecentralnervoussystem.AlsonamedparalysisagitansAffect1-2%ofpeopleover65yearsoldCauses:genes—DJ-1、PINKandsoonenvironmentalfactors:pesticidesDiseaseisprogressive–signs/symptomsworsenovertimeF
2、amouscasesNeurologicalBasisCellsinsubstantianigraproduce/releasedopaminDopaminereleasedbySNneuronslandsonneuronsofotherbraincenters,controllingtheirfiringMaintargetsarecaudatenucleusandputamen(corpusstriatum)ThisbasalgangliapathwayisinvolvedinregulationofmovementNeurologicalBas
3、isParkinson’sbrainfunction–BasalGangliaCellsofsubstantianigradegenerateThesecellscannolongerproduceadequateamountsofdopamineNeuronsofstriatum,etc.arenolongerwellregulated,thusdonotbehaveinnormalmannerResultsinlossofcontrolofmovements–leadstosymptomscharacteristicofParkinson’sdi
4、seaseEarlysymptomsofparkinson’sdiseasesMainsignsofparkinson’sdiseaseCharacteristicSymptomsMOTORtremorbradykinesiarigidity/freezinginplacelackoffacialexpressionposturalinstabilitystooped,shufflinggaitNONMOTORdiminishedsenseofsmelllowvoicevolumefootcrampssleepdisturbancedepressio
5、nconstipationdroolingNoEffectiveCureTreatmentofParkinson’sdiseaseThereisnocureforParkinson'sdisease,butmedicationsandsurgerycanproviderelieffromthesymptoms.Ihavenogoodidea！Drugsforparkinson’sdiseaseDrugsforparkinson’sdiseaseTheoraldopamineagonistsarenotaspotentaslevodopainallev
6、iatingparkinsonism,butarelesspronetocausedyskinesiaDopamineagonistsoftencausetheirownadverseeffectsinolderpatients,especiallyhallucinationsSelegilineandentacaponeprolongthedurationofactionoflevodopaAmantadinecanbeveryhelpfulinsuppressingdyskinesiaAnticholinergicdrugsareusefulfo
7、rtreatingtremor,buthavemuchlesseffectonparkinsonism,andoftenaggravatememoryproblemsThemainside-effectsoroverdosephenomenawhenenhancingthefailingnigrostriatalpathwaySurgicaltheatmentsaimedatinhibitingoveractivepartsofthebasalgangliacircuitrybyimplantinganelectrodestereotacticles
8、ionCareforyouself,awayfromParkinson'sdisease
