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1、黃芩苷對(duì)缺血性腦損傷雄性大鼠腦保護(hù)作用的機(jī)制研究摘要:H的觀察黃芩苷對(duì)缺血性腦損傷雄性大藏的腦保護(hù)作用及其對(duì)大鼠血清孕酮水平的影響,探討其可能的作用機(jī)制。方法采用成年SD雄性大鼠制造永久性左側(cè)大腦中動(dòng)脈梗阻模型,根據(jù)神經(jīng)功能評(píng)分,分為模型組、黃芩苷組和抑制劑組,假手術(shù)組不插入拴線。造模后于不同時(shí)間點(diǎn)進(jìn)行神經(jīng)功能評(píng)分及雙前肢抓力測(cè)定,計(jì)算抓力下降率;ELISA檢測(cè)血清孕酮和促腎上腺皮質(zhì)激素(ACTH)含量。結(jié)果與假手術(shù)組比較,模型組大鼠神經(jīng)功能受損,雙前肢抓力顯著減小。治療7d后,與模型組比較,黃芩苷組神經(jīng)功能評(píng)分降低,雙前肢抓力恢復(fù),
2、抓力下降率減?。≒〈0.05);與黃芩苷組比較,抑制劑組黃芩苷神經(jīng)功能保護(hù)作用降低(P〈0.05)。治療7d后,與模型組比較,黃芩苷組血清孕酮水平顯著升高(P〈0.01),ACTH水平有升高趨勢(shì);與黃芩苷組比較,抑制劑組血清孕酮和ACTH水平均降低(P〈0.05)。結(jié)論黃芩苷對(duì)缺血性腦損傷雄性大鼠的腦保護(hù)作用可能與其調(diào)控孕酮生成有關(guān)。本文采集自網(wǎng)絡(luò),本站發(fā)布的論文均是優(yōu)質(zhì)論文,供學(xué)習(xí)和研究使用,文中立場(chǎng)與本網(wǎng)站無關(guān),版權(quán)和著作權(quán)歸原作者所右,如存不愿意被轉(zhuǎn)載的情況,請(qǐng)通知我們刪除己轉(zhuǎn)載的信息,如果需要分享,請(qǐng)保留本段說明。關(guān)鍵詞:黃芩
3、苷;孕酮;促腎上腺皮質(zhì)激素;缺血性腦損傷;神經(jīng)功能;雄性大鼠DOI:10.3969/j.issn.1005-5304.2017.06.009中圖分類號(hào):R285.5文獻(xiàn)標(biāo)識(shí)碼:A文章編號(hào):1005-5304(2017)06-0035-04Abstract:ObjectiveToinvestigatetheproductiveeffectsofbaicalinonthemaleratswithischemicbraininjuryanditseffectsonserumprogesteronelevelinrats;Toexploret
4、hepossiblemechanismofbaicalininbrainprotection.MethodsAdultSDmaleratswereusedtocreateapermanentleftmiddlecerebralarteryocclusionmodel.Theratswereevenlydividedintomodelgroup,baicalingroup,inhibitorgroup,andsham-operationgroup(withoutinsertedintotheintraluminalthread)acco
5、rdingtotheneurologicalfunctionscores.Atdifferenttimepointsaftermodeling,theneurologicalfunctionscoresandthegripstrengthofdoubleforelegweremeasured,andthereductionrateofgripstrengthwascalculated.Scrumprogesteroneandadrenocorticotrophichormone(ACTII)weredetectedbyELISA.Re
6、sultsComparedwiththesham-operationgroup,theneurologicalfunctionofratsinthemodelgroupwasimpaired,thegripstrengthofdoubleforelegwassignificantlyreduced.7daysaftertreatment,comparedwiththemodelgroup,theneurologicalfunctionscoreofbaicalingroupwaslowered,gripstrengthofdouble
7、forelegwasrecovered,reductionrateofgripstrengthwasreduced(P<0.05);comparedwiththebaicalingroup,protectiveeffectsofbaicalinonneurologicalfunctionwasloweredininhibitorgroup(P<0.05).7daysaftertreatment,comparedwiththemodelgroup,theserumprogesteronelevelinbaicalingroupwassi
8、gnificantlyhigher(P〈0.01),andACTIIlevelshowedanincreasingtrend;comparedwiththebaicalingroup,serumprogesteronea