資源描述：
《含奧沙利鉑的新輔助動脈灌注化療治療進展期胃癌的臨床觀察》由會員上傳分享，免費在線閱讀，更多相關內(nèi)容在工程資料-天天文庫。
1、含奧沙利鈷的新輔助動脈灌注化療治療進展期胃癌的臨床觀察劉紅楊會利劉蔚莎郭春輝高玉凱（山東濱州市屮心醫(yī)院251700）【摘要】目的為研究新輔助介入化療治療進展期H癌的術后病理變化及臨床療效。方法對50例進展期胃癌隨機分為兩組，研宂組25例行含奧沙利鉑的動脈灌注化療；對照組25例行全身靜脈化療。前者采用seldinger技術，根據(jù)癌灶部位選擇相應的動脈插管，化療方案選擇奧沙利鉑85mg/m2,替加氟1000mg/m2、阿霉素25mg/m2o兩周期后7-10大手術治療；后者25例患者*選擇奧沙利鈾85mg/m2dl，亞葉酸弼20
2、0mg/m2dl-2,氟尿卩密陡400mg/m2ivdl-2,氟尿嘧啶600mg/m2CIVdl-2。兩周期全身化療后10-14天手術治療，對術后胃癌標本進行組織病理學檢查及術后2年生存率。結果兩組術后組織病理學改變總有效率分別55.6%,36.52%。兩組比較有統(tǒng)計學差異（P<0.05）。2年生存率分別為70%和54.2%兩組比較有統(tǒng)計學差異（P<0.05）。結論術前含奧沙利鉑的新輔助介入化療對進展期胃癌是一種安全有效、切實可行的輔助治療方法，并發(fā)癥少于全身化療，對手術切除率和生存率有提高，有待大祥本的研究?！娟P鍵詞】動
3、脈灌注化療進展期胃癌生存率【中圖分類號】R730.5【文獻標識碼】A【文章編號】1672-5085（2014）14-0050-02ClinicalobservationontheeffectofneoadjuvantintraarterialchemotherapyinthetreatmentofadvancedgastriccancerwithoxaliplatinLiuHongYangHuiliLiuWeishaGuoChunhuiGaoYukai,BinzhouCentralHospital,Shandong2517
4、00【Abstract】ObjectiveTostudyofneoadjuvantchemotherapyforadvancedgastriccancerpostoperativepathologicalchangesandclinicaleffect.Methods:50casesofadvancedgastriccancerwererandomlydividedintotwogroups,thestudygroupof25casesofarterialinfusionchemotherapywithoxaliplati
5、n;thecontrolgroupof25casesofsystemicvenouschemotherapy.TheformerusesSeldingertechnology,accordingtolesionlocationselectivearterialcorresponding,oxaliplatin85mg/m2chemotherapyregimentegafur,doxorubicin,1000mg/m225mg/m2.Thetwocycle7-10daysafteroperationtreatment;the
6、latter25patientsselected85mg/m2DIoxaliplatin,calciumfolinate200mg/m2Dl-2,fluorouracil400mg/m2ivdl-2,600mg/m2CIVdl-2fluorouracil.Thetwocycleofchemotherapytreatment10-14daysafteroperation,thepostoperativegastriccancerspecimensforexaminationandsurgerypathologyafter2y
7、earsurvivalrate.Results:thetwogroupsofpostoperativepathologychangeandtotaleffectiveratewere55.6%,36.52%.Asignificantdifferencebetweentwogroups(P<0.05).The2yearsurvivalrateswere70%and54.2%,asignificantdifferencebetweentwogroups(P<0.05).Conclusion:neoadjuvantp
8、reoperativeinterventionalchemotherapycontainingoxaliplatinisasafe,effective,feasibletreatmentmethodforadvancedgastriccancer,complicationslessthansystemi
