[精品]奧沙利鉑聯(lián)合腹腔熱灌注治療進展期胃癌的效果觀察.doc

《[精品]奧沙利鉑聯(lián)合腹腔熱灌注治療進展期胃癌的效果觀察.doc》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在工程資料-天天文庫。

1、奧沙利鉗聯(lián)合腹腔熱灌注治療進展期胃癌的效果觀察奧沙利鉗聯(lián)合腹腔熱灌注治療進展期胃癌的效果觀察［摘耍］目的探討奧沙利鉗聯(lián)合腹腔熱灌注治療胃癌的臨床應(yīng)用價值，為今后的臨床工作提供借鑒。方法選取2009年1月?2013年12月本院收治的80例胃癌患者，將其隨機分為治療組和對照組，每組各40例，兩組患者均采用亞葉酸鈣、奧沙利鉗、氟尿卩密噪進行化療，治療組在此基礎(chǔ)上增加腹腔熱灌注化療，觀察兩組患者的臨床療效。結(jié)果經(jīng)過2個周期的治療，治療組與對照組的總有效率分別為72.50%和62.50%,治療組顯著高于對照組(P<0.05)。其中治療組完全緩解(CR)

2、13例，CR率為32.50%。對照組CR10例，CR率為25.00%,實驗組顯著高于對照組(P〈0?05)。結(jié)論奧沙利鉗聯(lián)合腹腔熱灌注化療治療胃癌的臨床效果較單用化療藥物顯著。［關(guān)鍵詞］奧沙利鉗；腹腔熱灌注；進展期胃癌［中圖分類號］R735.2：文獻標識碼］A［文章編號］1674-4721(2014)06(b)-0071-03Effectobservationofoxaliplatincombiningwithhyperthermicperitonealperfusionchemotherapyontreatingadvancedgastri

3、ccarcinomaJTANGXiao~ineiYANGZhi-fengPENGJie~wenXTAOJian-junPeople'sHospitaiofZhongshanCityinGuangdongProvince,Zhongshan528400,China［Abstract］ObjectiveToexploretheclinicalapplicationvalueofoxaliplatincombiningwithhyperthermicperitonealperfusionchemotherapyontreatinggastrieca

4、rcinomainordertoprovidereferenceforclinicalworkinfuture?MethodsEightypatientswithgastriccarcinomaadmittedintoourhospitaifromJanuary2009toDecember2013wererandomlydividedintotreatmentgroupandcontrolgroup.Calciumfolinate,oxaliplatin,andfluorouracilwereprovidedforthetreatmentin

5、bothgroups?Onthisbasis,hyperthermicperitonealperfusionchemotherapywasadded.Theclinicaleffectinthetwogroupswasobserved.ResultsAftertwo-weektreatment,thetotaleffectiverateinthetreatmentgroupandcontrolgroupwas72.50%and62.50%respectively.Theindexinthetreatmentgroupwasremarkably

6、higherthanthatinthecontrolgroupwithastatisticaldifference(P<0.05).Thenumberofcompleteremissioninthetreatmentgroupwas13cases,accountingfor32.50%.Inthecontrolgroupwere10casesinCR,thecompleteremissionratewas25.00%.Aftercomparison,theformerwashigher,whichdisplayedastatisticaldi

7、fference(P<0.05).ConclusionTheclinicaleffectontreatingpatientwithgastriccarcinomaismoreremarkablebyoxaliplatincombiningwithhyperthermicperitonealperfusionchemotherapythanthatbychemotherapeuticdrugalone.［Keywords］Oxaliplatin;Hyperthermicperitonealperfusionchemotherapy:Advane

8、edgastriccarcinoma我國是胃癌發(fā)病大國，發(fā)病率、死亡率均排在惡性腫瘤的首位。胃癌早期癥狀不太明顯，大多數(shù)胃癌患者初次就診時已為晚期，臨床常釆用姑息性