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1、奧沙利鉗聯(lián)合腹腔熱灌注治療進(jìn)展期胃癌的效果觀察［摘要］目的探討奧沙利鉗聯(lián)合腹腔熱灌注治療胃癌的臨床應(yīng)用價值，為今后的臨床工作提供借鑒。方法選取2009年1月?2013年12月本院收治的80例胃癌患者，將其隨機(jī)分為治療組和對照組，每組各40例,兩組患者均采用亞葉酸鈣、奧沙利鉗、氟尿卩密噪進(jìn)行化療，治療組在此基礎(chǔ)上增加腹腔熱灌注化療，觀察兩組患者的臨床療效。結(jié)果經(jīng)過2個周期的治療，治療組與對照組的總冇效率分別為72.50%和62.50%,治療組顯著高于対照組(卩〈0.05)。其中治療組完全緩解(CR)13例,CR率為32.50%。對照組C
2、R10例，CR率為25.00%,實(shí)驗(yàn)組顯著高于對照組(P〈0?05)。結(jié)論奧沙利鉗聯(lián)合腹腔熱灌注化療治療胃癌的臨床效果較單用化療藥物顯著。［關(guān)鍵詞］奧沙利釦；腹腔熱灌注；進(jìn)展期胃癌［中圖分類號］R735.2E文獻(xiàn)標(biāo)識碼］A［文章編號］1674-4721(2014)06(b)-0071-03EffectobservationofoxaliplatincombiningwithhyperthermicperitonealperfusionchemotherapyontreatingadvaneedgastriccarcinomaJIANG
3、Xiao-meiYANGZhi-fengPENGJie-wenXIAOJian-junPeople'sHospitalofZhongshanCityinGuangdongProvince,Zhongshan528400,China[Abstract]ObjectiveToexploretheclinicalapplicationvalueofoxaliplatincombiningwithhyperthermicperitonealperfusionchemotherapyontreatinggastriecareinomainord
4、ertoprovidereferenceforclinicalworkinfuture?MethodsEightypatientswithgastriccarcinomaadmittedintoourhospitalfromJanuary2009toDecember2013wererandomlydividedintotreatmentgroupandcontrolgroup.Calciumfolinate,oxaliplatin,andfluorouracilwereprovidedforthetreatmentinbothgrou
5、ps.Onthisbasis,hyperthermicperitonealperfusionchemotherapywasadded.Theclinicaleffectinthetwogroupswasobserved.ResultsAftertwo-weektreatment,thetotaleffectiverateinthetreatmentgroupandcontrolgroupwas72.50%and62.50%respectively.Theindexinthetreatmentgroupwasremarkablyhigh
6、erthanthatinthecontrolgroupwithastatisticaldifference(P<0.05)?Thenumberofcompleteremissioninthetreatmentgroupwas13cases,accountingfor32.50%.Inthecontrolgroupwere10casesinCR,thecompleteremissionratewas25.00%.Aftercomparison,theformerwashigher,whichdisplayedastatisticaldi
7、fference(P<0.05).ConclusionTheclinicaleffectontreatingpatientwithgastriccarcinomaismoreremarkablebyoxaliplatincombiningwithhyperthermicperitonealperfusionchemotherapythanthatbychemotherapeuticdrugalone.[Keywords]Oxaliplatin;Hyperthermicperitonealperfusionchemotherapy;Ad
8、vancedgastriccarcinoma我國是胃癌發(fā)病大國，發(fā)病率、死亡率均排在惡性腫瘤的首位。胃癌早期癥狀不太明顯，大多數(shù)胃癌患者初次就診時已為晚期，臨床常采用姑息性化療，可以有效延長生存期，但是療效并不理想［1］
