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《血清vegf、血清vegf、opn濃度與進(jìn)展期胃癌術(shù)后復(fù)發(fā)關(guān)系的臨床研究》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在工程資料-天天文庫(kù)。
1、血清VEGF、OPN濃度與進(jìn)展期胃癌術(shù)后復(fù)發(fā)關(guān)系的臨床研究咸寧市中心醫(yī)院同濟(jì)咸寧醫(yī)院肝膽胰胃腸外科尹小平黎蔚浩朱棟良王代宏王偉王芳元*摘要：目的研究進(jìn)展期胃癌患者血清中血管內(nèi)皮生長(zhǎng)因子(VEGF)及骨橋蛋白(0P7)濃度與進(jìn)展期胃癌術(shù)后復(fù)發(fā)的關(guān)系，以探討其作為進(jìn)展期胃癌術(shù)后復(fù)發(fā)篩查標(biāo)記物的價(jià)值。方法采用酶聯(lián)免疫吸附試驗(yàn)法(ELTSA)檢測(cè)術(shù)前及術(shù)后不同時(shí)期40名進(jìn)展期胃癌患者血清中VEGF、OPN濃度，觀察其陽(yáng)性率、表現(xiàn)陽(yáng)性的時(shí)間與術(shù)后復(fù)發(fā)的關(guān)系，并與CEA、CA199及影像學(xué)檢查相比較。結(jié)果進(jìn)展期胃癌根治術(shù)后
2、血清VEGF、OPN濃度及陽(yáng)性率明顯下降，與術(shù)前比較其差異有統(tǒng)計(jì)學(xué)意義(戶<0.05)；術(shù)后轉(zhuǎn)移或復(fù)發(fā)患者血清VEGF、OPN濃度及陽(yáng)性率再次升高，與術(shù)后一月對(duì)比差異有明顯統(tǒng)計(jì)學(xué)意義(戶<0.01)；術(shù)后復(fù)發(fā)患者VEGF、OPN濃度及陽(yáng)性率明顯高于未復(fù)發(fā)者，差異有明顯統(tǒng)計(jì)學(xué)意義(P<0.01)；術(shù)前及術(shù)后復(fù)發(fā)時(shí)VEGF、OPN單獨(dú)檢測(cè)陽(yáng)性率高于CEA、CA199,其表現(xiàn)陽(yáng)性的吋間亦早于CEA、CA199,其差異均有統(tǒng)計(jì)學(xué)意義(PV0.05),聯(lián)合檢測(cè)吋前者亦高于后者，其差異均有統(tǒng)計(jì)學(xué)意義(戶<0.05)；血清V
3、EGF、OPN濃度升高表現(xiàn)陽(yáng)性的時(shí)間明顯早于胃鏡、CT等影像學(xué)檢查，其差異有統(tǒng)計(jì)學(xué)意義(PV0.05)。結(jié)論進(jìn)展期胃癌患者血清VEGF、OPN主耍由腫瘤組織分泌產(chǎn)生，術(shù)后監(jiān)測(cè)其血清濃度可用于早期預(yù)測(cè)和發(fā)現(xiàn)腫瘤的轉(zhuǎn)移復(fù)發(fā)。關(guān)鍵詞：血管內(nèi)皮生長(zhǎng)因子；骨橋蛋白；進(jìn)展期胃癌；復(fù)發(fā)ClinicalstudyabouttherelationshipofserumlevelsofVEGF,OPNandtherecurrenceofadvancedgastriccancerYINXiao-ping(LIWei-haoZHUDo
4、ng-liangWANGDai-hongWANGWei).DepartmentofGastrointestinalHepatobiliaryandPancreaticSurgery,XianningCenterHospital,Hubei437100,China.*Correspondingauthor:WANGFang-yuan(DepartmentofGastrointestinalHepatobiliaryandPancreaticSurgery,XianningCenterHospital,Hubei4
5、37100,China.)Abstract:ObjectiveToresearchtherelationshipofserumlevelsofVEGF>OPNandtherecurrenceofadvancedgastriccancer,anddiscussthevalueofVEGFandOPNasabiomarkertotherecurrenceofadvancedgastriccancer.MethodWedetected40advancedgastriccancerpatients^serumVEGF,
6、OPNconcentrationbeforeandafteroperationbythewayofenzyme-linkedimmunosorbentassay(ELISA).Thenweanalyzedtherelationshipbetweentheirpositiverates,thetimetheshowpositiveperformanceandtherecurrenceafteroperations,andcomparedwithCEA,CAI99andimagingexamination.Resu
7、ltComparedwiththepreoperativelevels,theconcentrationandpositiverateofVEGFandOPNdecreasedobviously,andthedifferencehasstatisticallysignificant(p<0.05).Comparedwiththetimeonemonthafteroperation,theconcentrationandpositiverateofVEGFandOPNriseagain,tothosepatien
8、tswhosuffermetastasisorrecurrenceafteroperation,andthedifferencehasstatisticallysignificant(p<0.01).Comparedwiththosepatientswhodidnotsuffermetastasisorrecurrence.patients"concentrationandpositi
