多沙唑嗪對(duì)映體對(duì)大鼠離體腸系膜微動(dòng)脈藥理作用的分析

《多沙唑嗪對(duì)映體對(duì)大鼠離體腸系膜微動(dòng)脈藥理作用的分析》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。

1、中文摘要的最大收縮效應(yīng)依次為：Phe=NA=Mox，Clo的最大收縮反應(yīng)僅為1．07％，Agm和Xyl未引起任何收縮反應(yīng)；0【受體激動(dòng)劑的效價(jià)強(qiáng)度依次為：NAO．05)，Clo與Xvl的最大反應(yīng)顯著增大至33．35％禾n1．74％(P

2、三級(jí)阻力血管標(biāo)本的最適前負(fù)荷，但是該標(biāo)準(zhǔn)化程序無(wú)法適用于大鼠離體腸系膜動(dòng)脈二級(jí)阻力血管標(biāo)本。2對(duì)于大鼠離體腸系膜動(dòng)脈二級(jí)、三級(jí)阻力血管標(biāo)本，(士)Dox阻斷0【，．腎上腺素受體的活性相似。(．)Dox對(duì)二級(jí)阻力血管O【1．腎上腺素受體的阻斷作用顯著弱于三級(jí)阻力血管，而(+)Dox呈現(xiàn)與(-)Dox相反的特征。3大鼠離體腸系膜動(dòng)脈二級(jí)阻力血管多次暴露于Q受體激動(dòng)劑后，表現(xiàn)出明顯的or2_I腎上腺素受體介導(dǎo)的血管收縮反應(yīng)。關(guān)鍵詞：多沙唑嗪對(duì)映體；Oil_11腎上腺素受體；(12-II腎上腺素受體；腸系膜微動(dòng)脈；最適前負(fù)荷；大鼠

3、英文摘要PharmacologicaleffectsofdoxazosinenantiomersintheratisolatedmesentericresistancearteriesABSTRACTObjective：Toanalysetheblockingeffectsof(一)doxazosin，(+)doxazosinand(+)doxazosinon(11一adrenoceptorsintheratisolatedmesentericresistancearteries，andobservethecharacte

4、risticsofVasoconstrictiVeresponsestoagmatine(Agm)and0【一adrenoceptoragonistsintheratisolatedmesentericresistancearteries．Methods：Preparationsofthesecondandthirdgenerationbranchesoftheratmesentericarteryweredissectedandprepared．Cumulativeconcentration-vasoconstricti

5、oncurvesfornoradrenaline(NA)，phenylephrine(Phe)，moxonidine(Mox)，c1．onidine(Clo)，xylazine(Xyl)andagmatine(Agm)wererecordedusingDMTwiremyographsystem620M．Results：1OptimalpreloaddeterminedinthesecondbranchoftheratmesentericarteryNormalizedpreloadscalculatedbytheDMTno

6、rmalizationsoftwarewere3．27士O．95mN(n=32)．Under5mNpreload，however,vasoconstrictiveresponsestoPheat3gmol·L～and300gmol·L。1weresignificantlylargerthanthatundernormalizedpreloads(P<0．05andP<0．01)．Ontheotherhand，vasoconstrictiveresponsetoPheat3gmol·L‘1wassignificantlysm

7、allerinthepreparationsunder10mNpreloadsthanthatundernormalizedpreloads(P<0．05)．Under20mNpreload，vasoconstrictiveresponsestoPheat3gmol·L。1，109mol·L‘1and300pmol·L。1weresignificantlysmallerthanthatundernormalizedpreloads儼

8、thirdbranchoftheratmesentericarteryNormalizedpreloadscalculatedbytheDMTnormalizationsoftwarewere1．09士O．33mN(n=7)．ThevaluesofEm。。and—LogECs0obtainedfromt