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《oct4介導(dǎo)fsh通過erk12信號(hào)通路誘導(dǎo)的上皮性卵巢癌上皮間質(zhì)轉(zhuǎn)化和侵襲作用》由會(huì)員上傳分享,免費(fèi)在線閱讀,更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。
1、OCT4介導(dǎo)FSH通過ERK1/2信號(hào)通路誘導(dǎo)的上皮性卵巢癌上皮間質(zhì)轉(zhuǎn)化和侵襲作用OCT4mediatesFSH-inducedepithelial-mesenchymaltransitionandinvasionthroughtheERK1/2signalingpathwayinepithelialovariancancer研究生姓名:劉磊研究生學(xué)號(hào):1127249498學(xué)科專業(yè):婦產(chǎn)科學(xué)導(dǎo)師:席曉薇教授導(dǎo)師組成員:豐有吉教授萬小平教授張?bào)鸩ㄑ芯繂T答辯日期:2015年4月29日碩士學(xué)位論文論文題目:OCT4介導(dǎo)FSH通過ERK1/2信號(hào)通路誘導(dǎo)的
2、上皮性卵巢癌上皮間質(zhì)轉(zhuǎn)化和侵襲作用作者姓名:劉磊指導(dǎo)教師:席曉薇教授學(xué)科專業(yè):婦產(chǎn)科學(xué)申請(qǐng)學(xué)位級(jí)別:碩士研究方向:婦科腫瘤培養(yǎng)單位:上海交通大學(xué)附屬第一人民醫(yī)院答辯日期:2015年4月29日資助基金項(xiàng)目:國(guó)家自然基金項(xiàng)目(81172478)SHANGHAIJIAOTONGUNIVERSITYMASTER'STHESISOCT4mediatesFSH-inducedepithelial-mesenchymaltransitionandinvasionthroughtheERK1/2signalingpathwayinepithelialovarian
3、cancerAUTHOR:LiuleiSUPERVISOR:ProfessorXiXiaoweiMAJOR:ObstetricsandGynecologyBACHELOR:MasterRESEARCHFIELDS:GynecologicOncologyUNIT:ShanghaiFirstPeople'sHospitalTHESISDEFENSE:April29,2015FUNDS:NationalNaturalScienceFoundationofChina(81172478)目錄摘要................................
4、.....................1第一部分FSH誘導(dǎo)上皮性卵巢癌發(fā)生上皮間質(zhì)轉(zhuǎn)化和侵襲...............161.1實(shí)驗(yàn)材料和方法............................................161.2結(jié)果...................................................291.3討論....................................................32第二部分FSH通過作用于FSHR上調(diào)OCT4表達(dá)...............
5、..........352.1實(shí)驗(yàn)材料和方法............................................352.2結(jié)果.....................................................372.3討論.....................................................40第三部分ERK1/2信號(hào)通路參與FSH誘導(dǎo)的OCT4和Snail的表達(dá)..........433.1實(shí)驗(yàn)材料和方法................................
6、............433.2結(jié)果.....................................................443.3討論.....................................................45第四部分OCT4是FSH誘導(dǎo)的上皮間質(zhì)轉(zhuǎn)化所必需的...................484.1實(shí)驗(yàn)材料和方法............................................484.2結(jié)果....................................
7、.................504.3討論.....................................................53第五部分OCT4介導(dǎo)FSH誘導(dǎo)的上皮性卵巢癌轉(zhuǎn)移.....................555.1實(shí)驗(yàn)材料和方法............................................555.2結(jié)果.....................................................565.3討論..............................
8、.......................58全文總結(jié)................................