補(bǔ)腎活血方治療帕金森病的臨床研究

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1、補(bǔ)腎活血方治療帕金森病的臨床研究補(bǔ)腎活血方治療帕金森病的臨床研究［摘要］目的觀察補(bǔ)腎活血方治療帕金森病的臨床效果。方法選擇西安交通大學(xué)第二附屬醫(yī)院2006年9月?2012年9月門診及住院帕金森病患者70例，將其隨機(jī)分為治療組(35例)和對(duì)照組(35例)，治療組給予補(bǔ)腎活血中藥和西藥美多巴，對(duì)照組單用美多巴，療程均為3個(gè)月，采用英國帕金森病學(xué)會(huì)腦庫帕金森病臨床診斷量表(UPDRS)對(duì)兩組患者治療前后的癥狀進(jìn)行評(píng)分；同時(shí)觀察兩組患者的非運(yùn)動(dòng)癥狀，包括失眠、便秘、多汗、精神障礙、乏力、不明原因?qū)е碌奶弁?、認(rèn)知障礙等的發(fā)生率。結(jié)

2、果治療組用藥前后的UPDRS評(píng)分差較對(duì)照組大，差異有統(tǒng)計(jì)學(xué)意義(P<0.05)；治療后治療組的非運(yùn)動(dòng)癥狀，如失眠、便秘、多汗、乏力的發(fā)生率與對(duì)照組比較，差異有統(tǒng)計(jì)學(xué)意義(P<0.05)；而精神障礙、不明原因?qū)е碌奶弁?、認(rèn)知障礙等雖較對(duì)照組有所降低，但差異無統(tǒng)計(jì)學(xué)意義(P>0.05)o結(jié)論補(bǔ)腎活血方可明顯改善帕金森病患者的運(yùn)動(dòng)癥狀，同時(shí)對(duì)于非運(yùn)動(dòng)癥狀如失眠、便秘、多汗、乏力等亦有明顯的改善。［關(guān)鍵詞］帕金森??；美多巴；藥物治療；中西醫(yī)結(jié)合［中圖分類號(hào)］R742.5［文獻(xiàn)標(biāo)識(shí)碼］A［文章編號(hào)］1673-7210(2014)0

3、8(a)-0099-04ClinicalstudyofParkinsondiseasetreatedwithBushenHuoxueDecoctionCHENSongshengMAQiaoyaWANGRuiliHUChuntingDepartmentofNeurology,CadreWard,theSecondAffiliatedHospitalofXi'anJiaotongUniversity,ShaanxiProvince,Xian710004,China［Abstract］ObjectiveToobservethe

4、clinicalefficacyofBushenHuoxueDecoctiononParkinsondisease?Methods70casesofParkinsondiseasewererandomlydividedintotreatmentgroup(35cases)andcontrolgroup(35cases)?Allthecasescamefromtheout-patientsandin-patientsoftheSecondAffiliatedHospitalofXianJiaotongUniversityf

5、romSeptember2006toSeptember2012.Intreatmentgroup,BushenHuoxueDecoctionandmadoparwereadministered?Incontrolgroup,madoparwasonlyadministered?Thedurationoftreatmentwas3months?TheunifiedParkinsondiseaseratingscale(UPDRS)wasusedtoscorethesymptomsandphysicalsignsbefore

6、andaftermedicationintwogroups?Theincidenceofnon-motorsymptomsoftwogroupswasobserved,includinginsomnia,profusesweating,mentaldisturbance,fatigue,unknownpain,cognitivedysfunction,etc??ResultsBeforeandaftertreatment,UPDRSscoresweremuchmoredifferentintreatmentgroupwh

7、encomparedwithcontrolgroup,indicatingastatisticallysignificantdifference(P<0.05)?Aftermedication,intreatmentgroup,ofnon-motorsymptoms,theincidencesofinsomnia,defecationdysfunction,profusesweatingandfatigueweresignificantlydifferentinstatisticswhencomparedwithcont

8、rolgroup(P<0.05)；andthoseofmentaldisturbance,unknownpainandcognitivedysfunctiondecreasedascomparedwithcontrolgroup,buttherewasnosignificantdifference(P>0.05)?C