冠狀病毒Coronavirusl論文-2012 Prevalence of Feline Coronavirus Antibodies in Japanese Domestic Cats during the Past Decade.pdf

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1、NOTEVirologyPrevalenceofFelineCoronavirusAntibodiesinJapaneseDomesticCatsduringthePastDecadeSatoshiTAHARAGUCHI1)*,TakehisaSOMA2)andMotonobuHARA1)1)DepartmentofMicrobiologyII,SchoolofVeterinaryMedicine,AzabuUniversity,1–17–71Fuchinobe,Chuo-ku,Sagamihara,Kan

2、agawa252–5201,Japan2)VeterinaryDiagnosticLaboratory,MarupiLifetechCo.,Ltd.,103Fushiocho,Ikeda,Osaka563–0011,Japan(Received26December2011/Accepted18May2012/PublishedonlineinJ-STAGE1June2012)AbSTRACT.From2001to2010,17,392Japanesecatswereexaminedforfelinecoro

3、navirus(FCoV)antibodies.Theseroprevalenceofpure-breds(66.7%)washigherthanthatofrandombreds(31.2%).Seroprevalenceincreasedgreatlyinpurebredsbythreemonthsofage,whileitdidnotfluctuategreatlyinrandombredswithaging,indicatingthatcatteryenvironmentscancontribute

4、toFCoVepidemics.PurebredsfromnorthernregionsofJapanwerelikelytobeseropositive(76.6%inHokkaido,80.0%inTohoku),indicatingcatterycatsincoldclimatesmightbemorecloselyconfined.Amongpurebreds,theAmericanshorthair,Himalayan,Oriental,Persian,andSiameseshowedlowser

5、oprevalence,whiletheAmericancurl,Mainecoon,Norwegianforestcat,ragdollandScottishfoldshowedhighseroprevalence.Therewouldalsobebreed-relateddifferencesinJapansimilartothepreviousstudiesinAustralia.KEYWORDS:domesticcat,felinecoronavirus,Japan,seroprevalence.d

6、oi:10.1292/jvms.11-0577;J.Vet.Med.Sci.74(10):1355–1358,2012Felinecoronavirus(FCoV)isapositivestrandedRNAal.[11].Inbrief,1.2×104Crandell-ReesefelinekidneyvirusthathasbeenclassifiedasaGroup1coronavirusalongcells/wellwereaddedto96-welltissuecultureplatesandwi

7、thcaninecoronavirus,transmissiblegastroenteritisvirusgrownovernightat37°C.Eachwellwasinoculatedwithandhumancoronavirus229Eandinfectsdomesticcatsand10TCID50ofanFIPvirus(FIPV)thatwasisolatedfromwildfelids.Itisshedinfecesbyhealthycats,istransmit-ascitesofaran

8、dombredcatwitheffusiveFIPinKanagawa,tedbythefecal-oralrouteandcausesmildtoinapparentJapan,in1996[3].ThisstrainofFIPVwasidentifiedasenteritis[7].FCoVisoflittleclinicalsignificanceexceptFCoVtypeIIusingananti-FC