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1、燈盞花素聯(lián)合福辛普利治療IgA腎病的療效觀察作者:劉曉渭,陳威,許國雙,孫世仁,劉宏寶,張鵬,白淑蓉【摘要】目的:觀察燈盞花素注射液聯(lián)合血管緊張素轉(zhuǎn)換酶抑制劑(ACEI)福辛普利治療IgA腎病(IgAN)的效果.方法:將64例Lee氏分級U?IV級的IgAN患者隨機(jī)分為燈盞花素+ACEI組(治療組)和ACEI組(對照組),每組32例,觀察兩組的療效.療效判定:①顯效:尿蛋白定量較治療前減少50%以上,尿沉渣檢測RBC<3個(gè)/Hp;血肌酹異常者降至正?;蜉^治療前下降>20%.②有效:尿蛋白定量較治療前減少30%?50%;尿沉渣檢測RBC<10個(gè)/Hp,計(jì)數(shù)
2、持續(xù)減少50%以上;血肌肝水平無變化或上升V20%.③無效:未達(dá)到上述標(biāo)準(zhǔn)者.結(jié)果:6個(gè)療程后,治療組24h尿蛋白定量及血尿減輕(P<0.01),血白蛋白水平升高(P<0.01)治療組32例中顯效12例,有效16例,總有效率為87.5%;對照組32例中顯效7例,有效9例,總有效率為50.0%?治療組血液流變學(xué)指標(biāo)改善,血肌肝水平,血脂下降水平優(yōu)于對照組.兩組患者用藥后均無明顯不良反應(yīng).結(jié)論:燈盞花素注射液聯(lián)合福辛普利治療IgAN安全有效,療效明顯優(yōu)于單用福辛普利者.【關(guān)鍵詞】IgA腎?。粺舯K花素注射液;血管緊張素轉(zhuǎn)換酶抑制劑;治療[Abstr
3、act]AIM:Toobservetheclinicalefficacyoffleabaneinjectioncombinedwithangiotensionconvertingenzymeinhibitor(ACEI)fosinoprilinthetreatmentofIgAnephropathy.METHODS:IgAnephropathycases(n=64)withII-IVdegreebyLeesclassificationwererandomlydividedinto2groups:treatmentgroup(fleabaneandfosi
4、nopril)andcontrolgroup(simplefosinopril)?Theirtherapeuticeffectswererecordedandanalysed?Therelavantevaluationofeffectsfellinto3types:①Excellence:Theurineproteinleveldecreasedbyover50%;RBCwaslessthan3perHp;AbnormalScrrecoveredtonormallevelordecreasedbyover20%comparedtopretreatment
5、?②Efficiency:Theurineproteinleveldecreasedby30%-50%;RBCwaslessthan10perHp;Scrlevelshowednochangeorincreasedbylessthan20%?③Inefficacy:Noanyabovechangeswasobserved?RESULTS:Sixmonthslater(30dasacourse),24hurineproteinexcretioninthepatientsoftreatmentgroupdecreasedsignificantly(P<
6、0?01vscontrolgroup),whilebloodalbuminincreasedgreatly(P<0.01vscontrolgroup).Thetotaleffectiveratewas87.5%intreatmentgroup,significantlysuperiortothatofcontrolgroup(50.0%).Theparametersinhemorheologywereimprovedandserumlevelofcreatininewasregulatedappropriatelyintreatmentgroup?
7、Thepatientsinthe2groupshadnoadverseeffectsaftertreatment.CONCLUSION:FleabaneinjectioncombinedwithfosinoprilforIgAnephropathyissafeandeffective?Itstherapeuticeffectisbetterthanthatofsimplefosinopriladministration?[Keywords]IgAnephropathy;fleabaneinjection;angiotensionconvertingenz
8、ymeinhib讓or;treatment0引言燈盞花素又名燈盞細(xì)辛,為菊科植物