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《燈盞花素聯(lián)合福辛普利治療IgA腎病的療效觀察（醫(yī)學(xué)論文）.doc》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在工程資料-天天文庫。
1、燈盞花素聯(lián)合福辛普利治療IgA腎病的療效觀察作者：劉曉渭，陳威，許國雙，孫世仁，劉宏寶，張鵬,白淑蓉【摘要】目的：觀察燈盞花素注射液聯(lián)合血管緊張素轉(zhuǎn)換酶抑制劑(ACEI)福辛普利治療IgA腎病(IgAN)的效果.方法：將64例Lee氏分級U?IV級的IgAN患者隨機(jī)分為燈盞花素+ACEI組(治療組)和ACEI組(對照組)，每組32例，觀察兩組的療效.療效判定：①顯效：尿蛋白定量較治療前減少50%以上，尿沉渣檢測RBC<3個(gè)/Hp;血肌酹異常者降至正?；蜉^治療前下降>20%.②有效：尿蛋白定量較治療前減少30%?50%;尿沉渣檢測RBC<10個(gè)/Hp,計(jì)數(shù)
2、持續(xù)減少50%以上；血肌肝水平無變化或上升V20%.③無效:未達(dá)到上述標(biāo)準(zhǔn)者.結(jié)果：6個(gè)療程后，治療組24h尿蛋白定量及血尿減輕(P<0.01),血白蛋白水平升高(P<0.01)治療組32例中顯效12例，有效16例，總有效率為87.5%;對照組32例中顯效7例，有效9例，總有效率為50.0%?治療組血液流變學(xué)指標(biāo)改善，血肌肝水平，血脂下降水平優(yōu)于對照組.兩組患者用藥后均無明顯不良反應(yīng).結(jié)論：燈盞花素注射液聯(lián)合福辛普利治療IgAN安全有效，療效明顯優(yōu)于單用福辛普利者.【關(guān)鍵詞】IgA腎?。粺舯K花素注射液；血管緊張素轉(zhuǎn)換酶抑制劑;治療[Abstr
3、act]AIM:Toobservetheclinicalefficacyoffleabaneinjectioncombinedwithangiotensionconvertingenzymeinhibitor(ACEI)fosinoprilinthetreatmentofIgAnephropathy.METHODS:IgAnephropathycases(n=64)withII-IVdegreebyLeesclassificationwererandomlydividedinto2groups:treatmentgroup(fleabaneandfosi
4、nopril)andcontrolgroup(simplefosinopril)?Theirtherapeuticeffectswererecordedandanalysed?Therelavantevaluationofeffectsfellinto3types:①Excellence:Theurineproteinleveldecreasedbyover50%;RBCwaslessthan3perHp;AbnormalScrrecoveredtonormallevelordecreasedbyover20%comparedtopretreatment
5、?②Efficiency:Theurineproteinleveldecreasedby30%-50%;RBCwaslessthan10perHp;Scrlevelshowednochangeorincreasedbylessthan20%?③Inefficacy:Noanyabovechangeswasobserved?RESULTS:Sixmonthslater(30dasacourse),24hurineproteinexcretioninthepatientsoftreatmentgroupdecreasedsignificantly(P<
6、0?01vscontrolgroup),whilebloodalbuminincreasedgreatly(P<0.01vscontrolgroup).Thetotaleffectiveratewas87.5%intreatmentgroup,significantlysuperiortothatofcontrolgroup(50.0%).Theparametersinhemorheologywereimprovedandserumlevelofcreatininewasregulatedappropriatelyintreatmentgroup?
7、Thepatientsinthe2groupshadnoadverseeffectsaftertreatment.CONCLUSION:FleabaneinjectioncombinedwithfosinoprilforIgAnephropathyissafeandeffective?Itstherapeuticeffectisbetterthanthatofsimplefosinopriladministration?[Keywords]IgAnephropathy;fleabaneinjection;angiotensionconvertingenz
8、ymeinhib讓or;treatment0引言燈盞花素又名燈盞細(xì)辛，為菊科植物
