資源描述：
《冠心病危險(xiǎn)因素的Logistic回歸及血小板聚集功能異常相.pdf》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫。
1、《心腦血管病防治》2009年4月第9卷 第2期 ·89··臨床研究·冠心病危險(xiǎn)因素的Logistic回歸及血小板聚集功能異常相關(guān)分析12潘建生,胡朝暉(11樂清市第二人民醫(yī)院,浙江樂清 325608;21復(fù)旦大學(xué)附屬中山醫(yī)院,上?！?00032)[摘 要] 目的 探討冠心病的各種危險(xiǎn)因素及與血小板聚集功能的相關(guān)性。方法 選擇64例住院患者,按照入選標(biāo)準(zhǔn)分為冠心病和對照組,分別問卷調(diào)查,生化檢測血脂、血糖等指標(biāo),放免法測定胰島素計(jì)算敏感指數(shù),用ADP誘導(dǎo)測定血小板聚集率,最后二分類Logistic多
2、元回歸分析篩選冠心病的危險(xiǎn)因素,并用偏相關(guān)分析法控制其他因素的影響后,分析重要因素與血小板聚集率的相關(guān)性。結(jié)果 Logistic回歸分析顯示性別、吸煙、空腹血糖、胰島素敏感指數(shù)及LDL-C與冠心病獨(dú)立相關(guān),并經(jīng)偏相關(guān)分析發(fā)現(xiàn),均與血小板聚集率有相關(guān)性,對照組無相關(guān)性。血小板聚集率與胰島素敏感指數(shù)、HDL-C負(fù)相關(guān)。結(jié)論 冠心病各主要危險(xiǎn)因素均與血小板聚集功能相關(guān),提示血小板可能在冠心病各方面都參與作用。[關(guān)鍵詞]冠心病;危險(xiǎn)因素;logistic回歸分析;血小板聚集率中圖分類號:R54114;R4
3、46111文獻(xiàn)標(biāo)識(shí)碼:A文章編號:1009-816X(2009)02-0089-03TheLogisticRegressionAnalysisofCoronaryDiseaseRiskFactorsandBivariateCorrelationwithAggregateFunctionofPlatelet.PANJian-sheng,HUChao-hui.DepartmentofCardiology,theSecondPeople’sHospitalofYueQing,ZheJiang325608
4、,China[Abstract]ObjectiveToanalysethevariousriskfactorsofCHDandinvestigatetheassociationwithaggregatefunctionofplateletinCHDpatients.Methods64inpatientsweredividedintoCHDandcontrolgroup.Questionnairewasinvestigatedseparately,plasmalipidsandsugarwerede
5、terminedbybiochemistrytest,theinsulinsensitiveindexwasmeasuredbyradioimmunoassay,theplateletag2gregateratewasmeasuredbyADP-inducingtest.AtlasttwosortslogisticmultipleregressionanalysiswasusedtoselectthemostimportantfactorsofCHD.Aftercontrollingtheaffe
6、ctsofotherfactorsbybivariatecorrelationanalysis,therelationshipbetweenthoseimportantfactorsandtheplateletaggregateratewasanalyzed.ResultsLogisticregressionanalysisshowedthatsex,smoking,fastplasmaglucose,insulinsensitiveindexandLDL-Careindependentriskf
7、actorsofCHD.Andtheyallhaveclosecorrelationwithplateletaggregaterate,whichisnegativecorrelationtoinsulinsensitiveindexandHDL-C.ConclusionsThemajorriskfactorsofCHDareallrelatedtoaggregatefunctionofplatelet.ItindicatesthatplateletmayaffectCHDinalldirecti
8、on.[Keywords]CHD;Riskfactor;Logisticregressionanalysis;Aggregaterateofplatelet 眾所周知,冠心病患者常伴諸多危險(xiǎn)因素,但每26例,男22例,女4例,年齡6017±1013歲;冠心病種危險(xiǎn)因素在冠心病形成中的權(quán)重目前尚不明確,血組:有典型心絞痛、心絞痛不典型或陳舊性心肌梗死小板功能異?？杉铀賱?dòng)脈粥樣硬化的形成及斑塊破史(經(jīng)心電圖、超聲心動(dòng)圖證實(shí)),冠脈造影狹窄≥裂,在冠心病的發(fā)生發(fā)展中的作用尤為重要,而冠
