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6、NAHOTAIR在腫瘤中的研究進(jìn)展庹磊,李蘇卿,汪春梅(綜述),曹秀峰(審校)(南京醫(yī)科大學(xué)附屬南京醫(yī)院腫瘤外科,南京210006)中圖分類號(hào):R73文獻(xiàn)標(biāo)識(shí)碼:A文章編號(hào):1006-2084(2014)16-2925-03doi:10.3969/j.issn.1006-2084.2014.16.017摘要:長(zhǎng)鏈非編碼RNA是多種生物學(xué)過(guò)程的關(guān)鍵調(diào)控因子,可在表觀遺傳學(xué)、轉(zhuǎn)錄及轉(zhuǎn)錄后等RNA(HOXtranscriptantisense多層面調(diào)控基因表達(dá),對(duì)個(gè)體生長(zhǎng)發(fā)育及腫瘤發(fā)生、發(fā)展過(guò)程至關(guān)重要。新近研究顯示,長(zhǎng)鏈非編碼RNA,HOTAIR)是迄今為止為RNA同源盒基因轉(zhuǎn)錄反義aNA(H
7、OTAIR)在多種實(shí)體腫瘤中均高表達(dá),且與腫瘤侵襲轉(zhuǎn)移、預(yù)后等數(shù)不多、功能和機(jī)制研究較為密切相關(guān)。該文對(duì)近年來(lái)HOTAIR在多種實(shí)體腫瘤中的研究進(jìn)展予以綜述。明確的LncRNA。該文主要關(guān)關(guān)鍵詞:同源盒基因轉(zhuǎn)錄反義RNA;長(zhǎng)鏈非編碼RNA;腫瘤注HOTAIR在多種腫瘤中表達(dá)、DevelopmentofLongNoneodingRNAHOTAIRinHumanNeoplasmTUOLei,LISu—qing,WANG功能及