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《免疫相關(guān)性血細(xì)胞減少患者血清細(xì)胞因子變化與骨髓免疫的相關(guān)性-論文.pdf》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫(kù)。
1、·6·實(shí)用醫(yī)藥雜志2014年O1月第31卷第0l期PracJMed＆Pharm．Vol31．2014—01No．01臨床醫(yī)學(xué)-論著·免疫相關(guān)性血細(xì)胞減少患者血清細(xì)胞因子變化與骨髓免疫的相關(guān)性崔東艷，吳強(qiáng)強(qiáng)，郝紅峰，岳青，杜延會(huì)[摘要]目的檢測(cè)89例免疫相關(guān)性血細(xì)胞減少(IRH／IRP)患者外周血細(xì)胞因子的變化狀況，觀察骨髓細(xì)胞活化狀態(tài)，探討IRH／IRP的免疫相關(guān)機(jī)制。方法ELISA方法檢測(cè)IRH／IRP患者外周血清IL一2、IL一4、IL一6和IFN一的含量，分析患者組和正常對(duì)照組間細(xì)胞因子含量的差異，并
2、對(duì)患者組Thl類細(xì)胞因子與Th2類細(xì)胞因子變化的相關(guān)性和升高率以及骨髓細(xì)胞免疫活化狀況與細(xì)胞因子變化的相關(guān)性進(jìn)行分析。結(jié)果89例患者血清IL一4、IL一6和IFN一呈現(xiàn)不同程度明顯升高(P<0．01)，其中IFN一顯著高于正常對(duì)照組，分別為(38．75±3．67)pg／ml和(8．69．4-1．68)pg／ml?；颊逿hl活化相關(guān)細(xì)胞因子的升高率與Th2活化相關(guān)細(xì)胞因子的升高率相比具有統(tǒng)計(jì)學(xué)差異。結(jié)論IFN一的變化與IRH／IRP者細(xì)胞免疫活化密切相關(guān)，IL一4和IL一6可能參與與IRI-I／IRP體液免疫
3、的活化，感染等可加重多重免疫活化，細(xì)胞因子含量和骨髓細(xì)胞免疫狀況的監(jiān)測(cè)有助于1RH／IRP的診斷并有利于評(píng)價(jià)患者的免疫機(jī)能狀態(tài)。[關(guān)鍵詞]免疫相關(guān)性血細(xì)胞減少；細(xì)胞免疫；Thl；Th2；體液免疫；細(xì)胞因子[中圖分類號(hào)]R392．7[文獻(xiàn)標(biāo)識(shí)碼]AAnalysisontherelativityofserumcytokineswithpatientSbonemarrowimmunityinimmunerelatedhemato-cytopeniaCUIDong—yan，WUQiang—qiang，HAOHong
4、—feng，eta1．DepartmentofClinicalLaboratory，Tai’anCen—tralHospital，Tai’an，Shandong271000，China[Abstract]ObjectiveToinvestigatetheimmunityrelatedpathogenicmechanismofIRH／IRPthroughdetectingbonemarrowimmunitystateassociatedwithselumcytokines．MethodsCellimmunit
5、yactivationofIRH／IRPpatientswereanalyzed．Theperipheralbloodof89patientswerecollectedwithasepsismethod．SerumconcentrationofcytokineIL一2，IL一4，IL一6andIFN一weredetectedbyELISAreagentkit．Thedisparityofconcentrationbetweenthepatientsgroupandthecontrolgroupwereana
6、lyzedbytteststatistically，thecorrelationanalysisofpatientgroupbetweenThlcytokinesandTh2cytokineswerealsoperformed．Thecorrelationbetweenmarrowcellimmunitystateandcytokineconcentrationwasanalyzed．ResultsSerumconcentrationofcytokineIL一4，IL一6andIFN一inpatientgr
7、oupwereincreaseddifferently(P<0．01)respectively．TheaverageserumlevelofcytokineIFN一wasofstatisticaldistinction(38．75±3．67VS8．69±1．68pg／m1)．TheincreaseratesbetweenThlcytokinesandTh2cytokinesofpatientswerealsosignificantly．ConclusionCytokineIFN一^，participates
8、inpathogenesisofcellimmunityinIRH／IRPpatients；IL一4andIL一6mayberelatedwithactivationofhumoralimmunity．Infectioncouldaggravatetheimmunityactivationandleadtoimmunologicinjury．Analysisofserumcytokineandcellimmuni
