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1、Chem.Rev.2010,110,272927552729LanthanideLuminescenceforBiomedicalAnalysesandImagingJean-ClaudeG.Bu¨nzli*LaboratoryofLanthanideSupramolecularChemistry,E′colePolytechniqueFe′de′raledeLausanne(EPFL),BCH1402,CH-1015Lausanne,Switzerland,andDepartmentofAdvancedMaterialsChemistry,WCUCenterfor
2、NextGenerationPhotovoltaicSystems,KoreaUniversity,SejongCampus,208Seochang,Jochiwon,ChungNam339-700,RepublicofKoreaReceivedNovember5,2009Contents1.Introduction27292.LanthanideLuminescence27302.1.BasicFacts27302.2.SensitizationbyOrganicLigands27322.3.InformationGainedfromLanthanide2732L
3、uminescentProbes2.3.1.HydrationNumbers27322.3.2.EnergyTransferandFRETExperiments27332.3.3.Collisional(Stern-Volmer)Quenching27342.4.DesigningEf?cientLanthanideLuminescent2735Bioprobes(LLBs)3.LanthanideBioconjugates27364.BioanalyseswithLanthanideLuminescentProbes2737Jean-ClaudeBu¨nzliis
4、anactiveresearcherinthe?eldofco-ordination,4.1.HeterogeneousImmunoassays2737supramolecular,andbiologicalchemistryofthelanthanideions.Heearned4.2.HomogeneousImmunoassays2738adegreeinchemicalengineeringin1968andaPh.D.in1971fromtheE′colePolytechniqueFe′de′raledeLausanne(EPFL).Hespenttwoye
5、ars4.3.Up-ConvertingPhosphorsand/orNanoparticles2740attheUniversityofBritishColumbia(Canada)andoneyearattheSwiss4.4.DeterminationofEnzymeActivity2740FederalInstituteofTechnologyinZu¨richbeforebeingappointedatthe4.1.1.pHProbes2741UniversityofLausannein1974andatEPFLin2001asafullprofessor
6、4.1.2.OxygenandSingletOxygenProbes2741ofinorganicchemistry.SinceSeptember2009,healsoholdsaWCUprofessorshipatKoreaUniversity,SejongCampus,Jochiwon,SouthKorea.4.2.3.HydrogenPeroxideProbes2742Hisresearchfocusesonthedesignand/orself-assemblyofbuildingblocks4.2.4.PhosphateProbes2742forphoto
7、luminescentmaterialsandlanthanideluminescentbioprobes,with4.2.5.EnzymeKinetics2743particularemphasisontheimagingofcancerouscellsandtissues.4.5.DNAAnalysis2743pathologicalanalysesaswellashighlycontrasted,real-time4.6.DetectionandQuanti?cationofSimple2746bioimages.Noninvasivemethodolog
