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1、遼寧中醫(yī)雜志2014年第41卷第5期·93l·DOI:IO.13192/j.issn.1000·1719.2014.05.043護(hù)肝降脂方治療非酒精性脂肪肝病臨床觀察隋晶,李軍祥(1.清華大學(xué)第一附屬醫(yī)院中醫(yī)科,北京100016;2.北京中醫(yī)藥大學(xué)附屬東方醫(yī)院,北京100078)摘要:目的:觀察自擬護(hù)肝降脂方對(duì)非酒精性脂肪肝病的,床療效,為,臨床治療非酒精性脂肪肝病提供新思路。方法:選取符合入選標(biāo)準(zhǔn)的病例61例,隨機(jī)分為兩組,治療組(32例,護(hù)肝降脂方治療),對(duì)照組(29例,水飛薊賓葡甲胺片治療),治療10周后觀察兩組患者
2、肝功、血脂水平及B超的變化。結(jié)果:兩組患者經(jīng)治療后,治療組與對(duì)照組的總有效率分別為87.5%和72.4%,治療組的總體療效明顯優(yōu)于對(duì)照組(P<0.05);治療前后肝功能和血脂檢測(cè)表明,治療后兩組肝功能(血清丙氨酸氨基轉(zhuǎn)移酶、天冬氨酸氨基轉(zhuǎn)移酶、一谷氨酰轉(zhuǎn)移酶)及血脂水平(血清總膽固醇、低密度脂蛋白膽固醇、甘油三酯)均有降低,但治療組較對(duì)照組有顯著統(tǒng)計(jì)學(xué)意義(P<0.05);治療后B超檢測(cè)表明,兩組患者脂肪肝程度均有改善,但治療組(84.4%)較對(duì)照組(65.5%)有顯著統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論:護(hù)肝降脂方對(duì)非酒精性
3、脂肪肝病有明確療效,值得在臨床推廣應(yīng)用。關(guān)鍵詞:護(hù)肝降脂方;非酒精性脂肪肝病;臨床療效中圖分類號(hào):R575.5文獻(xiàn)標(biāo)志碼:B文章編號(hào):1000.1719(2014)05-0931-03ClinicalObservationofNonalcoholicFattyLiverDiseaseTreatedwithMethodofHuganJianzhiFormulaSUIJing,LIJunxiang(1.DepartmentofChineseMedicineofTheFirstHospitalofTsinghuaUniversi
4、ty,Beijing100016,China;2.DongfangHospital,TheSecondClinicalMedicalCollegeofBeijingUniversityofChineseMedicine,Beijing100078,China)Abstract:ORctive:Toinvestigatetheclinicaleffectofthetreatmentofnonalcoholicfattyliverdisease(NAFLD)usingthemethodofHuganJianzhFormula.
5、Methods:61NAFLDcasesconformingtothediagnosticcriteriaandinclusioncriteriaweredi—videdintotwogroupsrandomly.Thetreatmentgroup(32eases)wastreatedwithHuganJianzhiFormulawhereasthecontrolgroupwastreatedwithSilibinMeglumineTabletsfor10weeks.Thepatientswereobservedliver
6、function,bloodlipidlevelsandB—ultrasonicimage.Results:Thetotaleffectiverateintreatmentgroupwas87.5%whereasthatincontrolgroupwas72.4%.Therewasasignificancedifferenceinthetwogroups(P<0.05).Meanwhile,liverfunctiontestsshowedthatalanineaminotrans.ferase(AIJT),aspartat
7、eaminotransferase(AST)andgamma—glutamyltranspeptidase(GGT)weresignificantlydecreasedinthetreatmentgroupthanthoseinthecontrolgroupaftertreatment(P<0.05).Bloodlipidlevels,includingtotalcholesterol(TC),lowdensitylipoproteincholesterin(LDL—C)andtriglyeeride(TG)weresig
8、nificantlydecreasedinthetreatmentgroupthanthoseinthecontrolgroupaftertreatment(P<0.05).B—testshowedthataftertreatment。thenorlTlalizationrateofB—ultra—so