缺氧誘導(dǎo)因子-1a血清水平與冠狀動(dòng)脈鈣化的相關(guān)性及臨床診斷價(jià)值.pdf

《缺氧誘導(dǎo)因子-1a血清水平與冠狀動(dòng)脈鈣化的相關(guān)性及臨床診斷價(jià)值.pdf》由會(huì)員上傳分享，免費(fèi)在線(xiàn)閱讀，更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫(kù)。

1、貴卅醫(yī)藥2015年3月第39卷第3期·207·缺氧誘導(dǎo)因子一1a血清水平與冠狀動(dòng)脈鈣化的相關(guān)性及臨床診斷價(jià)值曾慶娜黃山△許健馮勤穎張春陽(yáng)陳潔田禾劉志琴。王榮品(1．貴陽(yáng)醫(yī)學(xué)院醫(yī)學(xué)檢驗(yàn)學(xué)院，貴州貴陽(yáng)550004；2．貴州省人民醫(yī)院臨床檢驗(yàn)中心，貴州貴陽(yáng)550002；3．貴州省人民醫(yī)院心內(nèi)科，貴州貴陽(yáng)550002；4．貴州省人民醫(yī)院放射科，貴州貴陽(yáng)550002)摘要目的探討HIF-la血清水平與冠狀動(dòng)脈鈣化的關(guān)系及臨床診斷價(jià)值。．方法采用EIISA法檢測(cè)經(jīng)雙源CT檢查診斷為無(wú)鈣化積分和有不同鈣化積分的冠心病患者血清中HIF一1a水平，并進(jìn)行統(tǒng)計(jì)分

2、析，繪制其ROC曲線(xiàn)分析其診斷性能。結(jié)果HIF一1a在對(duì)照組與不同鈣化積分疾病組之間、以及對(duì)照組與疾病組之間其血清濃度水平差異顯著，疾病組中HIF_1a含量明顯高于對(duì)照組；鈣化積分與HIF一1a呈正相關(guān)(P<0．05)；ROC曲線(xiàn)顯示HIF一1a其曲線(xiàn)下面積為0．826，診斷閾值為56．53pg／mL，診斷敏感度為73．3O，特異性為73．50，Youden指數(shù)為0．517。結(jié)論HIF-1a在對(duì)照組和疾病組中表達(dá)不同，與鈣化積分呈正相關(guān)，對(duì)冠心病診斷價(jià)值明顯，對(duì)臨床預(yù)防和早期診斷冠心病起到了作用。關(guān)鍵詞缺氧誘導(dǎo)因子1a；冠心??；冠狀動(dòng)脈鈣化；

3、診斷價(jià)值Clinicaldiagnosisvalueandtherelationshipbetweenhypoxiainduciblefactor-1aserumlevelsandcoronaryarterycalcificationZengQingna，HuangShan，XuJian。，F(xiàn)engQinying，ZhangChunyang，ChenJie，TianHe，LiuZhiqin。，WangRongpin．1．GuiyangMedicineLaboratoryCollege，GuizhouMedicalUniversity，Guiy

4、ang550004，China．2．TheClinicalLaboratoryCenterofGuizhouPeople’SHospita1，Guiyang550002，China．3．DepartmentofCardiologyGuizhouPeople’SHospital，Guiyang550002，China．4．DepartmentofRadiologyofGuizhouPeople’SHospita1，Guiyang550002，China．Abstract0bjectiveToinvestigatetheclinicaldiagn

5、osisvalueofserumHIF—lalevelandtherelationshipbetweencoronaryarterycalcification．MethodBythetestofdualsourceCTinspectiondiagnosisfornoncalcificationscoreandserumHIF一1alevelinpatientswithcoronaryheartdiseaseindifferentcalcificationscorebyELISAmeth—od，andstatisticalanalysis，to

6、analyzethediagnosticperformanceoftheR0Ccurvedrawing．ResultHIF1abetweencontrolgroupanddifferentcalcificationdiseasesgroup，andbetweenthecontrolgroupandthegroupofdiseaseswhoseserumconcentrationlevelsignificantly，thecontentofHIF一1aindiseasegroupweresignificantlyhigherthanthecon

7、trolgroup．CalcificationscorewaspositivelycorrelatedwithHIF—la(P

8、easegroup，Calcificationwaspositivelyassociatedwithanobviouscoronaryheartdiseasedia