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《補(bǔ)肝益腎方對(duì)高血壓病早期腎損害尿微量蛋白及一氧化氮和內(nèi)皮素的影響.pdf》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫(kù)。
1、·740·WORLDCHINESEMEDICINEJune．2014，Vo1．9，No．6補(bǔ)肝益腎方對(duì)高血壓病早期腎損害尿微量蛋白及一氧化氮和內(nèi)皮素的影響高陸(天津市南開醫(yī)院心內(nèi)二科，天津，300000)摘要目的：觀察補(bǔ)肝益腎方對(duì)高血壓病早期腎損害患者尿微量蛋白、血漿一氧化氮(NO)及內(nèi)皮素一1(ET一1)的影v向，探討其療效及機(jī)制。方法：將164例高血壓病早期腎損害患者按數(shù)字表法隨機(jī)分為對(duì)照組和治療組，各82例，2組均給予包括厄貝沙坦在內(nèi)的降壓方案積極控制血壓，治療組聯(lián)合補(bǔ)肝益腎方治療，3個(gè)療程后對(duì)比2組治療前后動(dòng)態(tài)血壓、尿微量蛋白含
2、量及NO、ET一1血清水平。結(jié)果：2組24h平均收縮壓、24h平均舒張壓均較治療前明顯下降，治療組24h收縮壓變異系數(shù)、24h舒張壓變異系數(shù)均較治療前明顯下降，同時(shí)較對(duì)照組下降更為明顯，差異均有統(tǒng)計(jì)學(xué)意義(P<0．05)；2組尿微量蛋白含量及ET一1血清水平均較治療前下降，治療組均較對(duì)照組下降更為明顯，2組NO血清水平均較治療前升高，治療組升高更為明顯，差異均有統(tǒng)計(jì)學(xué)意義(P<0．05)。結(jié)論：補(bǔ)肝益腎方治療高血壓病早期腎損害，可平穩(wěn)控制血壓，減少尿微量蛋白排泄，抑制ET—l釋放，提高NO合成，改善血管活性，抑制病情進(jìn)展。關(guān)鍵詞補(bǔ)肝益腎
3、方；高血壓；尿微量蛋白；早期腎損害；內(nèi)皮功能EfectofBuganYishenFormulaonMicroalbuminuria，NitricOxideandEndothelinofPatientswithEarlyHypertensionRenalDamageGaoLu(CardiologyDepartmentTwoofTianjinNankaiHospital，Tianjin300000，China)AbstractObjective：ToobservetheeffectofBuganYishen(nourishinglivera
4、ndkidney)formulaonurinaryprotein，plasmanitricOX—ide(NO)andendothelin一1(ET一1)ofpatientswithearlyhypertensionrenaldamageandexploreitseffectandmechanism．Methods：Onehundredandsixtyfourpatientswithearlyrenaldamageofhypertensionwererandomlydividedintocontrolgroup(n=82)andob—se
5、rvationgroup(n=82)．BothgroupsgaveantihypertensivetherapyincludingMaherBbeChataintopositivelycontrolbloodpressure，andpatientsinthetreatmentgroupwerealsoBuganYishenformula．After3coursesoftreatment，thedynamicbloodpressure，urinetraceproteincontentandNO，ET一1serumlevelsofthetw
6、ogroupsbeforeandaftertreatmentwerecompared．Results：The24haveragesystol—icpressure，diastolicpressureof24hofpatientsinbothgroupsweresignificantlydecreasedaftertreatment；24hsystolicpressure，dias—tolicpressureof24hcoeficientofvariationofthetreatmentgroupweresignificantlydecr
7、easedaftertreatment，anddecreasedmoresignif-icantlythanthecontrolgroup，andthedifferenceswerestatisticallysignificant(P<0．05)；theurinaryproteincontentandET一1ofpa—tientsinbothgroupsdecreasedaftertreatment，andthetreatmentgroupdecreasedmoresignificantly；senlmNOlevelsofgroupsi
8、n—creasedaftertreatment，andthetreatmentgroupincreasedmoresignificantlyandthedifferenceswerestatisticall
