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1、第23卷第3期化學研究中國科技核心期刊2012年5月CHEMICALRESEARCHhxyj@henu．edu．cnSynthesis，crystalstructureandbiologicalactivityofdiacetylferrocene—S—methyldithi0carbazateSchiff-baseYANGMin，HEHong—ju，LIYan-ke，LIMing—xue(1．CollegeofChemistryandChemicalEngineering，HenanUniversity，Kaifeng475004，
2、Henan，China；2．HenanSeniorTechnicianSchoolofChemicalIndustry，Kaifeng475002，Henan，China)Abstract：Aferrocene—containingSchiff—baseligand，[(CH3)SSCNHN—C(CH3)(C5H4)]2Fe，wassynthesizedbyusingdiacetylferroceneandS—methy1dithiocarbazateasthestartingmateri—als．Thecomposition，che
3、micalfeatureandcrystalstructureofas—synthesizedproductwereanalyzedbymeansofelementalanalysis，infraredspectrometryandsingle—crystalX-raydiffrac—tion；anditsbiologicalactivitywasevaluated．Resultsindicatethatthetitlecompoundexhibitsmoderateanticanceractivityinthecellgrowthi
4、nhibitionoftheEc9706humanoesophaguscancercel1line．Keywords：ferrocene；S～methyldithiocarbazate；Schiff—base；synthesis；crystalstructure；bio—logicalactivitycLCnumber：O641Documentcode：AArticleID：】008一】0】】(2O】2)03一OO76—06雙乙酰二茂鐵縮肼基二硫代甲酸甲酯Schiff堿的合成、晶體結構和生物活性楊敏，賀紅舉，李彥克，李明雪(1．河南大
5、學化學化工學院，河南開封475004；2．河南化學工業(yè)技師學院，河南開封475002)摘要：用雙乙酰二茂鐵和肼基二硫代甲酸甲酯為起始原料，制備了含二茂鐵的Schiff堿配體[(CH。)SSCNHN—c(CH。)(cH)]Fe．利用元素分析以及紅外光譜和單晶X射線衍射分析了產(chǎn)物的組成、化學特征及晶體結構，并測定了其生物活性．結果表明，標題化合物對Ec9706食管癌細胞株具有適度的生長抑制活性．關鍵詞：二茂鐵；肼基二硫代甲酸甲酯；Schiff堿合成；晶體結構；生物活性Inthesearchfornewanticancerdrugs，met
6、alcomplexesandorganometalliccompoundshavearousedconsiderableinterest，duetothetremendousSuccessofclinicallyimportantmetal—basedanticancerdrug，cis—diamminedichloroplatinum(cis一[PtC12(NH3)2])．Recently，studyonseveralferrocenederivativeswithpromisingbiologicalpropertiesshows
7、thattheincorporationofaferrocenefragmentintothemoleculeoforganiccompoundsoftenleadstounexpectedbiologicalactivity[。一．Itisalsoreportedthattheadditionofferrocenemoietytothestructuresofsomedrugsresultsinenhancedactivities[．Furthermore，ferro—ceneisknownasachemicallyandtherm
8、allystableorganometalliccompound[．Thestability，non—toxici—tyandgoodmembrane—permeationabilityoftheferrocenylgr
