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1、大連醫(yī)科大學(xué)碩士學(xué)位論文結(jié)論：1、胃間質(zhì)瘤臨床表現(xiàn)無(wú)特異性，術(shù)前確診率較低，仍需完善胃間質(zhì)瘤的檢查技術(shù)，提高確診率。2、手術(shù)仍是治療胃間質(zhì)瘤的首選方案，應(yīng)盡可能做到完整切除病灶，對(duì)于中高危患者，應(yīng)同時(shí)輔以甲磺酸伊馬替尼治療。3、對(duì)于術(shù)后出現(xiàn)復(fù)發(fā)或轉(zhuǎn)移的可能性較大的患者，應(yīng)定期隨診，尤其在術(shù)后2年內(nèi)。即使出現(xiàn)復(fù)發(fā)、轉(zhuǎn)移，也應(yīng)積極爭(zhēng)取再次手術(shù)，同時(shí)配合甲磺酸伊馬替尼輔助治療。關(guān)鍵詞：胃間質(zhì)瘤免疫組化伊馬替尼預(yù)后2大連醫(yī)科大學(xué)碩士學(xué)位論文Clinicalanalysisof87PatientswithGastricStromalTumorMasterdegreecandidate：LuK
2、ebinSupervisor：ProfessorTianDayuVice—supervisor：ProfessorHuXiangMajor：GeneralSurgeryAbstractobjecfiveToinvestigatetheclinicalcharacteristics，diagnosis，treatmentandprognosisofdecisionfactorsofgastricstromaltumor．MethodsClinicaldataof87patientswithgastricstromaltumorfromJanuary2008toJanuary2013w
3、ereanalyzed．ResultsThepatientsofGastricstromaltumorhavedifferentclinicalmanifestations，lackofpatientswithtypicalclinicalmanifestmions．Themainclinicalmanifestationwerebloodystools，abdominalpainanddistension．Thediagnosisbeforeoperationismainlydependedongastroscope，CT，MIU，ColorDopplerUltrasoundto
4、findtheplaceholderlesionsinthestomach，butonly12patients(13．7％)achievedpreoperativepathologicaldiagnosis．Thepatientsofhigh—lowrisk，lowrisk，intermediaterisk，andhighriskwas13cases(14．9％)，27cases(31．1％)，25cases(28．7％)，and22cases(25．3％)，respectively．Therearethreekindsofpostoperativepathologytypes，s
5、pindlecelltype(75％)，epithelioidcelltype(17．6％)andmixedtype(7．4％)．Comparedthelevelofriskandthehistologicaltype(accordingtothe貯，貯=0．6786，P>0．05)，therewasnostatisticallysignificantdifference，thereisnorelationshipbetweenlevelofriskandthehistologicaltype．immunohistochemistry：CD17positivein81patient
6、s(93．1％)，73casesofCD34positive(83．9％)，17casewasSMApositive，11casesofS-100positive．Allpatientsunderwentsurgicalresection，65partialgastrectomy，16subtotalgastrectomy，5totalgastrectomy，lcombinedmultipleorgansresection．61patientswerefollowed-upfor8-50months(average34months)．Thepatientsofhigh—lowris
7、k，lowrisk，intermediaterisk，andhighriskwas7cases，12cases，21cases，and21cases，respectively．Comparedthetumordiameterofsurvivalgroupanddeathgroupinmedium—highriskpatients(accordingtothet，t=5．85，P
