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1、openaccesswww.bioinformation.netHypothesisVolume8(10)StudiesonNewDelhiMetallo-Beta-Lactamse-1producingAcinetobacterbaumanniiisolatedfromdonorswabinatertiaryeyecarecentre,IndiaandstructuralanalysisofitsantibioticbindinginteractionsMuraliSowmiya1,VetrivelUma
2、shankar2,SivashanmuganMuthukumaran2,HajibNarahariraoMadhavan1&JambulingamMalathi1*1L&TMicrobiologyResearchCentre,VisionResearchFoundation,SankaraNethralaya,New.41(Old.No18),Chennai–600006India;2CentreofBioinformatics,VisionResearchFoundation,SankaraNethral
3、aya,Chennai,India;JambulingamMalathi-Email:drjm@snmail.org;Phone:-+914428220709;Fax:+914428254180;*CorrespondingauthorReceivedMay07,2012;AcceptedMay10,2012;PublishedMay31,2012Abstract:Gram-negativebacilli,EnterobacteriaceaeandNon-fermentorswithresistanceto
4、carbapenemsandmetallobeta-lactamsarethemajorcauseofconcerninclinicalproblemsincurrenthumanhealthcare.ThemosthighlyemergingdreadfulMetalloBeta-lactamsesisNewDelhimetallo-beta-lactamase(blaNDM-1)whichconfersresistancetocarbapenems;susceptibleonlytocolistinan
5、d,lessconsistentlytotigecycline,leadingtonotherapeuticoptions.Inthepresentstudy,wedemonstratetheeffectsofcephalosporinsandcarbepenemsonbiofilmproducingA.baumaniiclinicalisolateandalsotoinfertheprobableinhibitorybindingmodethroughmoleculardockingstudies.The
6、resultofMIConBiofilmproducingA.baumaniiandthedockinganalysisresultswerefoundtobeconcordant.Moreover,wealsofoundcephalosporinsandcarbepenemgroupstointeractwith162-166regionofblaNDM-1,whichisuniqueforNDM-1andalsodocumentedtobeapotentialdrugtargetingregion.Ba
7、ckground:posedbyinfectioncausingmicrobes[5,6].RecentstudieshasAntibiotic-resistantGram-negativebacillibelongingtoprovedtheinactivationofthesecarbapenams(meropenem,EnterobacteriaceaeandNon-fermentorsarethemajorcauseofimipenem,doripenem,ertapenem)byanumberof
8、metallo-concerninclinicalproblemsincurrenthumanhealthcare[1,2]beta-lactamaseswhichposesextendedspectrumactivityagainstBeta-lactamshavebeenthemainstayoftreatmentforseriousallbeta-lactamantibiotics,includingcar
