資源描述：
《老年膿毒癥血漿氨基末端腦鈉肽前體和肌鈣蛋白i 的臨床價值.doc》由會員上傳分享，免費在線閱讀，更多相關內容在工程資料-天天文庫。
1、老年膿毒癥血漿氨基末端腦鈉肽前體和肌鈣蛋白I的臨床價值【摘?！磕康耐ㄟ^聯合檢測老年膿毒癥患者血漿氨基末端腦鈉肽前體(NT-proBNP)和肌鈣蛋白I(cTnl)質量濃度，評價其對老年膿毒癥患者的病情評估及預后判斷的臨床意義。方法用前瞻性研究方法，以2011年1月至2013年1月在解放軍總醫(yī)院第一附屬醫(yī)院急診留觀及急診病房住院的老年膿毒癥患者145例為研究對象，其屮一般膿毒癥組84例、嚴重膿毒癥組45例、膿毒性休克組16例。來院后立即檢測血漿NT-proBNP和cTnl質量濃度，行超聲心動圖檢查測定LVEF值，進行A
2、PACHEII評分。隨訪嚴重膿毒癥及膿毒性休克組患者28d生存情況，對存活組(49例)及死亡組(12例)患者檢測的各項指標進行比較；并比較NT-proBNP和cTnl與APACHEII評分的相關性。結果血漿NT-proBNP和cTnl在嚴重膿毒癥組［(1375.48±537.15)pg/mL,(0.53±0.45)ug/L］和膿毒性休克組［(2735.73±907.17)pg/mL,(1.94±1.14)ug/L］的質量濃度明顯高于一般膿毒癥組［(554.12±107.48)pg/mL,(0.08±0.07)ug/
3、L］,三組間比較差異均具有統計學意義(卩〈0.01)；死亡組血漿NT-proBNP.cTnT質量濃度及APACHEII評分均明顯高于存活組，LVEF值明顯低于存活組，差異具有統計學意義；血漿NT-proBNP和cTnT質量濃度與APACHEII評分呈正相關。結論血漿NT-proBNP和cTnl質量濃度可用于膿毒癥患者的病情評估及預后判斷。【關鍵詞】老年人；膿毒癥；嚴重膿毒癥；膿毒性休克；氨基末端腦鈉肽前體；肌鈣蛋白I;射血分數；預后ClinicalvalueofN-terminalpro-brainnatriure
4、ticpeptideandtroponinTplasma1eveIsinelderlypatientswithsepsisSUQin,ZHANGXian,YaoYa-bin,CHENLi-ping,GAOShi-bo,LIUDong-sheng,LIUYang,YAOYong-ming,ZHAOXiao-dong.DepartmentofEmergency,FirstAffiliatedHospital,GeneralHospitalofPLA,Beijing100048,China[Abstract】Object
5、iveToevaluatetheclinicalsignificaneeforassessmentandprognosisofdetectingplasmaNT~proBNPprospectivetrialconducted.sepsiswereadmittedtotheemergencywardfromJanuaryelderpatientswithsepsisbywayofandcTnllevels.MethodsitwasaAtotalof145elderlypatientswithemergencyobse
6、rvationcenterandthe2011throughJanuary2013.Ofthem,therewere84patientswithmildsepsis,45patientswithseveresepsis,and16patientswithsepticshock.PlasmalevelsofNT-proBNPandcTnlwereassayediminediatelyafteradmission.TheLVEFvaluewasdeterminedbyechocardiography.TheAPACHE
7、IIscorewasalsodetermined.Tnthefollowing28daysthesurvivalofpatientswithseveresepsisandsepticshockwereinvestigated?Dataoflaboratoryfindingswereanalyzedforcomparisonbetweenthesurvivalgroup(n二49)anddeathgroup(n=12)?ResuItsTheplasmalevelsofNT-proBNPandcTnlintheseve
8、resepsisgroup[(1375.48±537.15)pg/mL,(0.53±0.45)ug/L]andinthesepticshockgroup[(2735.73土907.17)pg/mL,(1.94±1.14)ug/L]weresignificantlyhigherthanthoseinthemildsepsisgroup[(554.12±107.
