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1、上海交通大學學報(醫(yī)學版)JournalofShanghaiJiaotongUniversity(MedicalScience)1681[文章編號]1674—8115(2013)12—1681—03·短篇論著·兩種不同麻醉方式對患者圍手術(shù)期應激的影響仲勇,周嘉,袁嵐(上海中醫(yī)藥大學附屬曙光醫(yī)院麻醉科,上海201203)[摘要]目的探討兩種不同麻醉方式對患者圍手術(shù)期應激的影響。方法按配對設計原則選擇腹部手術(shù)治療的患者62例,分為單純?nèi)砺樽斫M(A組)和全身麻醉復合硬膜外阻滯組(B組),每組31例,分別于麻醉誘導前(T,)、手術(shù)開始后30rain(
2、T)、關(guān)腹后(T)和術(shù)后24h(T),記錄患者心率、平均動脈血壓(MABP),測血漿去甲腎上腺素(NE)、血清皮質(zhì)醇(Cot)和血清c反應蛋白(CRP)濃度。術(shù)后記錄患者手術(shù)時間及出血量。結(jié)果兩組患者手術(shù)時間和出血量比較差異均無統(tǒng)計學意義(P>0.05);T、T和T時間點,B組患者MABP均低于A組患者(P<0.05),T時兩組患者MABP比較差異無統(tǒng)計學意義(P>0.05);T,~T各時間點兩組患者心率比較差異無統(tǒng)計學意義(P>0.05);T。時間點,B組NE水平明顯高于A組(P<0.01),但兩組問Cor、CRP比較差異無統(tǒng)計學意義(P>0
3、.05);T、T、T時間點,B組NE、Cor和CRP水平均顯著低于A組(P<0.01或P<0.05)。結(jié)論全身麻醉復合硬膜外阻滯較單純?nèi)砺樽砀芙档突颊邍中g(shù)期應激反應。[關(guān)鍵詞]全身麻醉;硬膜外阻滯;去甲腎上腺素;皮質(zhì)醇;C反應蛋白[DOI]10.3969/j.issn.1674—8115.2013+12.027[中圖分類號]R614.2;R614.42[文獻標志碼]BStressinperioperativeperiodoftwodifferentanesthesiamethodsZHONGYong,ZHOUJia,YUANLan(Dep
4、artmentofAnesthesiology,ShuguangHospital,ShanghaiUniversityofTraditionalChineseMedicine,Shanghai201203China)【Abstract】ObjectiveToexplorestressinperioperativeperiodoftwodifferentanesthesiamethods.MethodsAccordingtomatchingdesign,62patientsunderwentabdominalsurgerywereselected
5、anddividedintogeneralanesthesiagroup(groupA)andgeneralanesthesiacombinedwithepiduralblockgroup(groupB)with31ineach.Heartrate(HR),meanarterialbloodpressure(MABP),plasmanorepinephrine(NE),serumcortisol(Cor),andserumC—reactiveprotein(CPR)concentrationweremeasuredinthebeginningo
6、fanesthesia(T1),30minafterbeginning(T2),abdominalsuture(T),and24hafteroperation(T4).Operationtimeandamountofbleedingwererecorded.ResultsTherewere1osignificantdifferencesofoperationtimeandbleedingbetweenthetwogroups(尸>0.05).ComparedtogroupA,MABPvaluesweresignificantlylowerinp
7、atientsofgroupBinT1,T2,andT3timepoints(P<0.05),butMABPvaluesweresimilarinTd(P>0.05).TheHRvalueswerenormalinbothgroups.InTl,theNElevelsofBgroupweresignificantlyhigher(P<0.01),buttherewerenosignificantdifferencesofCorandCRPvalues.InT2,T3,andT4timepoints,theNE,Cor,andCRPvaluesw
8、eresignificantlyloweringroupBthanthoseofgroupA(P<0.05,P<0.o1).ConclusionGen